1whi

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[[Image:1whi.jpg|left|200px]]
 
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==RIBOSOMAL PROTEIN L14==
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The line below this paragraph, containing "STRUCTURE_1whi", creates the "Structure Box" on the page.
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<StructureSection load='1whi' size='340' side='right'caption='[[1whi]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1whi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whi OCA], [https://pdbe.org/1whi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whi RCSB], [https://www.ebi.ac.uk/pdbsum/1whi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whi ProSAT]</span></td></tr>
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{{STRUCTURE_1whi| PDB=1whi | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL14_GEOSE RL14_GEOSE] Forms part of two intersubunit bridges in the 70S ribosome (By similarity). Binds to 23S rRNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/1whi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1whi ConSurf].
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<div style="clear:both"></div>
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'''RIBOSOMAL PROTEIN L14'''
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==See Also==
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*[[Ribosomal protein L14|Ribosomal protein L14]]
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__TOC__
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==Overview==
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</StructureSection>
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BACKGROUND: Detailed structural information on ribosomal proteins has increased our understanding of the structure, function and evolution of the ribosome. L14 is one of the most conserved ribosomal proteins and appears to have a central role in the ribonucleoprotein complex. Studies have indicated that L14 occupies a central location between the peptidyl transferase and GTPase regions of the large ribosomal subunit. RESULTS: The crystal structure of L14 from Bacillus stearothermophilus has been solved using a combination of isomorphous replacement and multiwavelength anomalous dispersion (MAD) methods. The structure comprises a five-stranded beta-barrel, a C-terminal loop region that contains two small alpha-helices, and a beta-ribbon that projects from the beta-barrel. An analysis of the structure and the conserved amino acids reveals three surface patches that probably mediate L14-RNA and L14-protein interactions within the ribosome. CONCLUSIONS: The accepted role of ribosomal proteins is to promote the folding and stabilization of ribosomal RNA. The L14 structure is consistent with this notion, and it suggests that the RNA binds in two sites. One RNA-binding site appears to recognize a distinct region of ribosomal RNA during particle assembly. The second site is smaller and may become occupied during the later compaction of the RNA. The surface hydrophobic patch is a likely site of protein-protein interaction, possibly with L19.
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==About this Structure==
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1WHI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHI OCA].
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==Reference==
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The crystal structure of ribosomal protein L14 reveals an important organizational component of the translational apparatus., Davies C, White SW, Ramakrishnan V, Structure. 1996 Jan 15;4(1):55-66. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8805509 8805509]
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[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Davies, C.]]
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[[Category: Davies C]]
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[[Category: Ramakrishnan, V.]]
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[[Category: Ramakrishnan V]]
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[[Category: White, S W.]]
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[[Category: White SW]]
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[[Category: Ribosomal protein]]
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[[Category: Rrna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:40:43 2008''
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Current revision

RIBOSOMAL PROTEIN L14

PDB ID 1whi

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