1wm7

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[[Image:1wm7.jpg|left|200px]]
 
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==Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch, 9 structures==
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The line below this paragraph, containing "STRUCTURE_1wm7", creates the "Structure Box" on the page.
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<StructureSection load='1wm7' size='340' side='right'caption='[[1wm7]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wm7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WM7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wm7 OCA], [https://pdbe.org/1wm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wm7 RCSB], [https://www.ebi.ac.uk/pdbsum/1wm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wm7 ProSAT]</span></td></tr>
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{{STRUCTURE_1wm7| PDB=1wm7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAX82_MESMA KAX82_MESMA] Blocks small conductance calcium-activated potassium channels (KCNN, SK). Low toxicity by intracerebroventricular injection into mice.<ref>PMID:22511981</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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From the venom of scorpion Buthus martensii Karsch,a short peptide (BmP01, 29 amino acid residues) was isolated and characterized as previously reported (Lebren, R. R., et al. (1997) Eur. J. Biochem. 245, 457-464). It was shown to reduce 33% outward K(+) channel (hippocampal neurons) currents at 10 microM. The solution structure of BmP01 was determined by 2D (1)H NMR spectroscopy. The NOEs, coupling constants, and H-D exchange obtained from NMR spectroscopy were used in structural calculations. The conformation of BmP01 is composed of a short alpha-helix (Cys 3-Thr 12) and a two-stranded antiparallel beta-sheet (Ala 15-Asp 20 and Lys 23-Pro 28). There are three disulfide bridges (Cys 3-Cys 19, Cys 6-Cys 24 and Cys 10-Cys 26) connecting the alpha-helix and beta-sheet. Asp 20 to Lys 23 form a type II turn linking the two strands. Structural and electrostatic potential comparison between BmP01 and its analogues are also presented.
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'''Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch, 9 structures'''
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Solution structure of BmP01 from the venom of scorpion Buthus martensii Karsch.,Wu G, Li Y, Wei D, He F, Jiang S, Hu G, Wu H Biochem Biophys Res Commun. 2000 Oct 5;276(3):1148-54. PMID:11027603<ref>PMID:11027603</ref>
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==Overview==
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From the venom of scorpion Buthus martensii Karsch,a short peptide (BmP01, 29 amino acid residues) was isolated and characterized as previously reported (Lebren, R. R., et al. (1997) Eur. J. Biochem. 245, 457-464). It was shown to reduce 33% outward K(+) channel (hippocampal neurons) currents at 10 microM. The solution structure of BmP01 was determined by 2D (1)H NMR spectroscopy. The NOEs, coupling constants, and H-D exchange obtained from NMR spectroscopy were used in structural calculations. The conformation of BmP01 is composed of a short alpha-helix (Cys 3-Thr 12) and a two-stranded antiparallel beta-sheet (Ala 15-Asp 20 and Lys 23-Pro 28). There are three disulfide bridges (Cys 3-Cys 19, Cys 6-Cys 24 and Cys 10-Cys 26) connecting the alpha-helix and beta-sheet. Asp 20 to Lys 23 form a type II turn linking the two strands. Structural and electrostatic potential comparison between BmP01 and its analogues are also presented.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1WM7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM7 OCA].
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</div>
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<div class="pdbe-citations 1wm7" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Solution structure of BmP01 from the venom of scorpion Buthus martensii Karsch., Wu G, Li Y, Wei D, He F, Jiang S, Hu G, Wu H, Biochem Biophys Res Commun. 2000 Oct 5;276(3):1148-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11027603 11027603]
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*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mesobuthus martensii]]
[[Category: Mesobuthus martensii]]
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[[Category: Single protein]]
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[[Category: Chen X]]
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[[Category: Chen, X.]]
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[[Category: He F]]
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[[Category: He, F.]]
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[[Category: Hu G]]
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[[Category: Hu, G.]]
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[[Category: Jiang S]]
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[[Category: Jiang, S.]]
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[[Category: Li Y]]
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[[Category: Li, Y.]]
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[[Category: Wei D]]
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[[Category: Wei, D.]]
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[[Category: Wu G]]
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[[Category: Wu, G.]]
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[[Category: Wu H]]
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[[Category: Wu, H.]]
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[[Category: Alpha/beta scaffold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:52:01 2008''
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Current revision

Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch, 9 structures

PDB ID 1wm7

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