1wmw

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[[Image:1wmw.gif|left|200px]]
 
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==Crystal structure of geranulgeranyl diphosphate synthase from Thermus thermophilus==
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The line below this paragraph, containing "STRUCTURE_1wmw", creates the "Structure Box" on the page.
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<StructureSection load='1wmw' size='340' side='right'caption='[[1wmw]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wmw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WMW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmw OCA], [https://pdbe.org/1wmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wmw RCSB], [https://www.ebi.ac.uk/pdbsum/1wmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmw ProSAT], [https://www.topsan.org/Proteins/RSGI/1wmw TOPSAN]</span></td></tr>
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{{STRUCTURE_1wmw| PDB=1wmw | SCENE= }}
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</table>
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== Function ==
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'''Crystal structure of geranulgeranyl diphosphate synthase from Thermus thermophilus'''
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[https://www.uniprot.org/uniprot/Q5SMD0_THET8 Q5SMD0_THET8]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Geranylgeranyl diphosphate (GGPP) synthase from Thermus thermophilus HB8 was expressed in Escherichia coli, purified to homogeneity and crystallized both as the recombinant native protein and its selenomethionine (SeMet) derivative. Well diffracting crystals of these proteins were obtained belonging to the tetragonal space group P4(1) or P4(3), with unit-cell parameters a = b = 139.88, c = 73.37 A. There were two homodimers in the asymmetric unit. A native data set was collected to 1.55 A resolution and a data set suitable for MAD phasing was collected to 2.40 A resolution on beamline BL40B2 at SPring-8.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/1wmw_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1WMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMW OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wmw ConSurf].
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Expression, purification, crystallization and preliminary X-ray studies of geranylgeranyl diphosphate synthase from Thermus thermophilus HB8., Nishio K, Nodake Y, Hamada K, Suto K, Nakagawa N, Kuramitsu S, Miura K, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):178-80. Epub 2003, Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14684922 14684922]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: Thermus thermophilus]]
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</StructureSection>
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[[Category: Hamada, K.]]
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[[Category: Large Structures]]
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[[Category: Kawamoto, M.]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Kuramitu, S.]]
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[[Category: Hamada K]]
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[[Category: Miura, K.]]
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[[Category: Kawamoto M]]
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[[Category: Nakagawa, N.]]
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[[Category: Kuramitu S]]
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[[Category: Nishio, K.]]
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[[Category: Miura K]]
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[[Category: Nodake, Y.]]
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[[Category: Nakagawa N]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Nishio K]]
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[[Category: Suto, K.]]
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[[Category: Nodake Y]]
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[[Category: Ggpp]]
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[[Category: Suto K]]
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[[Category: Prenyl diphosphate synthase]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Thermus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:53:30 2008''
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Current revision

Crystal structure of geranulgeranyl diphosphate synthase from Thermus thermophilus

PDB ID 1wmw

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