1wn0

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[[Image:1wn0.gif|left|200px]]
 
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==Crystal Structure of Histidine-containing Phosphotransfer Protein, ZmHP2, from maize==
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The line below this paragraph, containing "STRUCTURE_1wn0", creates the "Structure Box" on the page.
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<StructureSection load='1wn0' size='340' side='right'caption='[[1wn0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wn0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WN0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn0 OCA], [https://pdbe.org/1wn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wn0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wn0 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wn0 TOPSAN]</span></td></tr>
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{{STRUCTURE_1wn0| PDB=1wn0 | SCENE= }}
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</table>
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== Function ==
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'''Crystal Structure of Histidine-containing Phosphotransfer Protein, ZmHP2, from maize'''
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[https://www.uniprot.org/uniprot/Q9SLX1_MAIZE Q9SLX1_MAIZE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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In higher plants, histidine-aspartate phosphorelays (two-component system) are involved in hormone signaling and stress responses. In these systems, histidine-containing phosphotransfer (HPt) proteins mediate the signal transmission from sensory histidine kinases to response regulators, including integration of several signaling pathways or branching into different pathways. We have determined the crystal structure of a maize HPt protein, ZmHP2, at 2.2 A resolution. ZmHP2 has six alpha-helices with a four-helix bundle at the C-terminus, a feature commonly found in HPt domains. In ZmHP2, almost all of the conserved residues among plant HPt proteins surround this histidine, probably forming the docking interface for the receiver domain of histidine kinase or the response regulator. Arg102 of ZmHP2 is conserved as a basic residue in plant HPt proteins. In bacteria, it is replaced by glutamine or glutamate that form a hydrogen bond to Ndelta atoms of the phospho-accepting histidine. It may play a key role in the complex formation of ZmHP2 with receiver domains.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/1wn0_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1WN0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN0 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wn0 ConSurf].
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Crystal structure of the histidine-containing phosphotransfer protein ZmHP2 from maize., Sugawara H, Kawano Y, Hatakeyama T, Yamaya T, Kamiya N, Sakakibara H, Protein Sci. 2005 Jan;14(1):202-8. Epub 2004 Dec 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576555 15576555]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Zea mays]]
[[Category: Zea mays]]
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[[Category: Hatakeyama, T.]]
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[[Category: Hatakeyama T]]
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[[Category: Kamiya, N.]]
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[[Category: Kamiya N]]
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[[Category: Kawano, Y.]]
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[[Category: Kawano Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Sakakibara H]]
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[[Category: Sakakibara, H.]]
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[[Category: Sugawara H]]
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[[Category: Sugawara, H.]]
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[[Category: Yamaya T]]
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[[Category: Yamaya, T.]]
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[[Category: Four-helix bundle]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:53:42 2008''
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Current revision

Crystal Structure of Histidine-containing Phosphotransfer Protein, ZmHP2, from maize

PDB ID 1wn0

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