1wn8

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[[Image:1wn8.jpg|left|200px]]
 
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==NMR Structure of OaNTR==
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The line below this paragraph, containing "STRUCTURE_1wn8", creates the "Structure Box" on the page.
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<StructureSection load='1wn8' size='340' side='right'caption='[[1wn8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oldenlandia_affinis Oldenlandia affinis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WN8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn8 OCA], [https://pdbe.org/1wn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wn8 RCSB], [https://www.ebi.ac.uk/pdbsum/1wn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wn8 ProSAT]</span></td></tr>
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{{STRUCTURE_1wn8| PDB=1wn8 | SCENE= }}
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</table>
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== Function ==
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'''NMR Structure of OaNTR'''
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[https://www.uniprot.org/uniprot/KAB3_OLDAF KAB3_OLDAF] Probably participates in a plant defense mechanism. Has hemolytic activity.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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The cyclotides are the largest family of naturally occurring circular proteins. The mechanism by which the termini of these gene-encoded proteins are linked seamlessly with a peptide bond to form a circular backbone is unknown. Here we report cyclotide-encoding cDNA sequences from the plant Viola odorata and compare them with those from an evolutionarily distinct species, Oldenlandia affinis. Individual members of this multigene family encode one to three mature cyclotide domains. These domains are preceded by N-terminal repeat regions (NTRs) that are conserved within a plant species but not between species. We have structurally characterized peptides corresponding to these NTRs and show that, despite them having no sequence homology, they form a structurally conserved alpha-helical motif. This structural conservation suggests a vital role for the NTR in the in vivo folding, processing, or detoxification of cyclotide domains from the precursor protein.
The cyclotides are the largest family of naturally occurring circular proteins. The mechanism by which the termini of these gene-encoded proteins are linked seamlessly with a peptide bond to form a circular backbone is unknown. Here we report cyclotide-encoding cDNA sequences from the plant Viola odorata and compare them with those from an evolutionarily distinct species, Oldenlandia affinis. Individual members of this multigene family encode one to three mature cyclotide domains. These domains are preceded by N-terminal repeat regions (NTRs) that are conserved within a plant species but not between species. We have structurally characterized peptides corresponding to these NTRs and show that, despite them having no sequence homology, they form a structurally conserved alpha-helical motif. This structural conservation suggests a vital role for the NTR in the in vivo folding, processing, or detoxification of cyclotide domains from the precursor protein.
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==About this Structure==
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Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins.,Dutton JL, Renda RF, Waine C, Clark RJ, Daly NL, Jennings CV, Anderson MA, Craik DJ J Biol Chem. 2004 Nov 5;279(45):46858-67. Epub 2004 Aug 24. PMID:15328347<ref>PMID:15328347</ref>
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1WN8 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN8 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins., Dutton JL, Renda RF, Waine C, Clark RJ, Daly NL, Jennings CV, Anderson MA, Craik DJ, J Biol Chem. 2004 Nov 5;279(45):46858-67. Epub 2004 Aug 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15328347 15328347]
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</div>
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[[Category: Single protein]]
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<div class="pdbe-citations 1wn8" style="background-color:#fffaf0;"></div>
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[[Category: Anderson, M A.]]
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== References ==
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[[Category: Clark, R J.]]
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<references/>
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[[Category: Craik, D J.]]
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__TOC__
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[[Category: Daly, N L.]]
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</StructureSection>
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[[Category: Dutton, J L.]]
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[[Category: Large Structures]]
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[[Category: Jennings, C V.]]
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[[Category: Oldenlandia affinis]]
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[[Category: Renda, R F.]]
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[[Category: Anderson MA]]
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[[Category: Waine, C.]]
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[[Category: Clark RJ]]
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[[Category: Helix]]
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[[Category: Craik DJ]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:54:18 2008''
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[[Category: Daly NL]]
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[[Category: Dutton JL]]
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[[Category: Jennings CV]]
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[[Category: Renda RF]]
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[[Category: Waine C]]

Current revision

NMR Structure of OaNTR

PDB ID 1wn8

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