1woq

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[[Image:1woq.jpg|left|200px]]
 
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==Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution==
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The line below this paragraph, containing "STRUCTURE_1woq", creates the "Structure Box" on the page.
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<StructureSection load='1woq' size='340' side='right'caption='[[1woq]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1woq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_sp._KM Arthrobacter sp. KM]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WOQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1woq| PDB=1woq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1woq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1woq OCA], [https://pdbe.org/1woq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1woq RCSB], [https://www.ebi.ac.uk/pdbsum/1woq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1woq ProSAT]</span></td></tr>
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</table>
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'''Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q7WT42_ARTSK Q7WT42_ARTSK]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Inorganic polyphosphate (poly(P)) is a biological high energy compound presumed to be an ancient energy carrier preceding ATP. Several poly(P)-dependent kinases that use poly(P) as a phosphoryl donor are known to function in bacteria, but crystal structures of these kinases have not been solved. Here we present the crystal structure of bacterial poly(P)/ATP-glucomannokinase, belonging to Gram-positive bacterial glucokinase, complexed with 1 glucose molecule and 2 phosphate molecules at 1.8 A resolution, being the first among poly(P)-dependent kinases and bacterial glucokinases. The poly(P)/ATP-glucomannokinase structure enabled us to understand the structural relationship of bacterial glucokinase to eucaryotic hexokinase and ADP-glucokinase, which has remained a matter of debate. These comparisons also enabled us to propose putative binding sites for phosphoryl groups for ATP and especially for poly(P) and to obtain insights into the evolution of kinase, particularly from primordial poly(P)-specific to ubiquitous ATP-specific proteins.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/1woq_consurf.spt"</scriptWhenChecked>
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1WOQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arthrobacter_sp. Arthrobacter sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WOQ OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of bacterial inorganic polyphosphate/ATP-glucomannokinase. Insights into kinase evolution., Mukai T, Kawai S, Mori S, Mikami B, Murata K, J Biol Chem. 2004 Nov 26;279(48):50591-600. Epub 2004 Sep 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15377666 15377666]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1woq ConSurf].
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[[Category: Arthrobacter sp.]]
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<div style="clear:both"></div>
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[[Category: Polyphosphate--glucose phosphotransferase]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Kawai, S.]]
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[[Category: Arthrobacter sp. KM]]
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[[Category: Mikami, B.]]
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[[Category: Large Structures]]
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[[Category: Mori, S.]]
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[[Category: Kawai S]]
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[[Category: Mukai, T.]]
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[[Category: Mikami B]]
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[[Category: Murata, K.]]
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[[Category: Mori S]]
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[[Category: Atp]]
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[[Category: Mukai T]]
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[[Category: Glucomannokinase]]
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[[Category: Murata K]]
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[[Category: Polyphosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:57:23 2008''
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Current revision

Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution

PDB ID 1woq

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