Ion channels 3D structures

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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* Potassium channel See: [[Potassium_Channel#Additional_Structures_of_Potassium_Channels|Potassium Channels]]
 
*Calcium channel
*Calcium channel
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**[[2d46]] – hVDCC 4a – NMR – human
+
**[[2d46]] – hVDCC beta 4a – NMR – human
**[[6nq0]], [[6nq1]], [[6nq2]] – hTpc2 – Cryo EM <br />
**[[6nq0]], [[6nq1]], [[6nq2]] – hTpc2 – Cryo EM <br />
**[[8if4]] – hCav alpha-2+delta-1 – Cryo EM <br />
**[[8if4]] – hCav alpha-2+delta-1 – Cryo EM <br />
**[[8if3]] – hCav alpha-2+delta-1 + drug – Cryo EM <br />
**[[8if3]] – hCav alpha-2+delta-1 + drug – Cryo EM <br />
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**[[2be6]], [[2f3y]], [[2f3z]] – hCav1.2 1C subunit+calmodulin
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**[[2be6]], [[2f3y]], [[2f3z]] – hCav1.2 alpha 1C subunit+calmodulin
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**[[3oxq]] - hCav2.1 1C subunit IQ domain+hCalmodulin
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**[[3oxq]] - hCav2.1 alpha 1C subunit IQ domain+hCalmodulin
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**[[2vay]], [[3oxq]] – hCav1.1 1S subunit IQ domain+hCalmodulin
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**[[2vay]], [[3oxq]] – hCav1.1 alpha 1S subunit IQ domain+hCalmodulin
**[[8eoi]] – hCav1.2 in EMC chaperone – Cryo EM <br />
**[[8eoi]] – hCav1.2 in EMC chaperone – Cryo EM <br />
**[[8fd7]] – hCav1.2 + drug – Cryo EM <br />
**[[8fd7]] – hCav1.2 + drug – Cryo EM <br />
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**[[7mix]] – hCav2.2C + conotoxin – Cryo EM <br />
**[[7mix]] – hCav2.2C + conotoxin – Cryo EM <br />
**[[7xlq]], [[8epl]], [[8epm]] – hCav2.3 – Cryo EM <br />
**[[7xlq]], [[8epl]], [[8epm]] – hCav2.3 – Cryo EM <br />
- 
**[[6kzo]] – hCav3.1C – Cryo EM <br />
**[[6kzo]] – hCav3.1C – Cryo EM <br />
**[[6kzp]] – hCav3.1C + antagonist – Cryo EM <br />
**[[6kzp]] – hCav3.1C + antagonist – Cryo EM <br />
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**[[6jpa]], [[6jpb]] – rCav1.1 + blocker – Cryo EM<br />
**[[6jpa]], [[6jpb]] – rCav1.1 + blocker – Cryo EM<br />
**[[8e56]], [[8e57]], [[8e58]] – rCav1.1 + drug – Cryo EM<br />
**[[8e56]], [[8e57]], [[8e58]] – rCav1.1 + drug – Cryo EM<br />
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**[[3bxx]] – rCav2.1 1A subunit+calmodulin
+
**[[3bxx]] – rCav2.1 alpha 1A subunit+calmodulin
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**[[3bxl]] - rCav2.3 1E subunit+calmodulin
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**[[3bxl]] - rCav2.3 alpha 1E subunit+calmodulin
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**[[1t0h]] – rVDCC 2A subunit
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**[[1t0h]] – rVDCC beta 2A subunit
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**[[1t0j]] – rVDCC 2A+ 1C
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**[[1t0j]] – rVDCC beta 2A+ 1C
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**[[1vyt]] - rVDCC 3+ 1C
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**[[1vyt]] - rVDCC beta 3+ 1C
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**[[1vyu]] – rVDCC 3
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**[[1vyu]] – rVDCC beta 3
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**[[1vyv]] - rVDCC 4
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**[[1vyv]] - rVDCC beta 4
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**[[6hw2]] - rVDCC 4 + chromobox protein<br />
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**[[6hw2]] - rVDCC beta 4 + chromobox protein<br />
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**[[1t3l]] - rVDCC 2+ 1S
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**[[1t3l]] - rVDCC beta 2+ 1S
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**[[1t3s]] - rVDCC 2
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**[[1t3s]] - rVDCC beta 2
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**[[3dve]], [[3dvj]], [[3dvk]], [[3dvm]], [[3g43]] - rCav2.2 1B subunit+hCalmodulin
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**[[3dve]], [[3dvj]], [[3dvk]], [[3dvm]], [[3g43]] - rCav2.2 alpha 1B subunit+hCalmodulin
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**[[4dex]] - rCav2.2 1B + 2 subunits<br />
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**[[4dex]] - rCav2.2 alpha 1B + beta 2 subunits<br />
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**[[4dey]] - rCav2.2 1C + 2 subunits<br />
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**[[4dey]] - rCav2.2 alpha 1C + beta 2 subunits<br />
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**[[6byo]] – rCav1.1 1S <br />
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**[[6byo]] – rCav1.1 alpha 1S <br />
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**[[5gjw]] – rCav1.1 2/d 1 + 1S + 1 – Cryo EM<br />
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**[[5gjw]] – rCav1.1 alpha 2/d 1 + alpha 1S + beta 1 – Cryo EM<br />
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**[[3jbr]], [[5gjv]] – rCav1.1 2/d 1 + 1S + 1 + g 1 – Cryo EM<br />
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**[[3jbr]], [[5gjv]] – rCav1.1 alpha 2/d 1 + alpha 1S + beta 1 + gamma 1 – Cryo EM<br />
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**[[5v2p]], [[5v2q]] - raCav1.2 1C + 2 - rat<br />
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**[[5v2p]], [[5v2q]] - raCav1.2 alpha 1C + beta 2 - rat<br />
**[[7qhh]] - raVDCC g 8 + glutamate receptor 1 – Cryo EM<br />
**[[7qhh]] - raVDCC g 8 + glutamate receptor 1 – Cryo EM<br />
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**[[5kk2]], [[5vov]], [[5vou]], [[5vot]] - raVDCC g 2 + glutamate receptor 2 – Cryo EM<br />
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**[[5kk2]], [[5vov]], [[5vou]], [[5vot]] - raVDCC gamma 2 + glutamate receptor 2 – Cryo EM<br />
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**[[6njl]], [[6njm]], [[6njn]] - raVDCC g 2 + glutamate receptor 1 + glutamate receptor 2 + a’/c’ auxiliary protein + antibody – Cryo EM<br />
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**[[6njl]], [[6njm]], [[6njn]] - raVDCC gamma 2 + glutamate receptor 1 + glutamate receptor 2 + a’/c’ auxiliary protein + antibody – Cryo EM<br />
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**[[6qkc]], [[6qkz]], [[7ocd]] - raVDCC g 8 + glutamate receptor 1 + glutamate receptor 2 – Cryo EM<br />
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**[[6qkc]], [[6qkz]], [[7ocd]] - raVDCC gamma 8 + glutamate receptor 1 + glutamate receptor 2 – Cryo EM<br />
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**[[7oca]], [[7oce]], [[7ocf]] - raVDCC g 8 + glutamate receptor 1 + glutamate receptor 2 + CNIH-2 – Cryo EM<br />
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**[[7oca]], [[7oce]], [[7ocf]] - raVDCC gamma 8 + glutamate receptor 1 + glutamate receptor 2 + CNIH-2 – Cryo EM<br />
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**[[8e0e]] – raCav L-type 2 + nanobody<br />
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**[[8e0e]] – raCav L-type beta 2 + nanobody<br />
**[[6c96]], [[6c9a]] – mTpc1 - mouse – Cryo EM <br />
**[[6c96]], [[6c9a]] – mTpc1 - mouse – Cryo EM <br />
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**[[4zw2]] – mVDCC 1S peptide + 1 <br />
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**[[4zw2]] – mVDCC alpha 1S peptide + beta 1 <br />
**[[7lep]] - mVDCC g 8 + glutamate receptor 2 + AMPAR subunits + CNIH-2 – Cryo EM<br />
**[[7lep]] - mVDCC g 8 + glutamate receptor 2 + AMPAR subunits + CNIH-2 – Cryo EM<br />
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**[[8dam]] – mCav L-type 1 + nanobody<br />
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**[[8dam]] – mCav L-type beta 1 + nanobody<br />
**[[5dqq]], [[5e1j]], [[5tua]], [[7fhk]], [[7fhl]] – AtTpc1 – Arabidopsis thaliana <br />
**[[5dqq]], [[5e1j]], [[5tua]], [[7fhk]], [[7fhl]] – AtTpc1 – Arabidopsis thaliana <br />
**[[6cx0]] – AtTpc1 (mutant) <br />
**[[6cx0]] – AtTpc1 (mutant) <br />
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*Potassium channel see [[Potassium Channel]]
*Potassium channel see [[Potassium Channel]]
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NH4+ channel
+
*NH4+ channel
**[[1u77]], [[1u7c]], [[1u7g]], [[1xqe]], [[1xqf]], [[2nmr]], [[2nop]], [[2now]], [[2npc]], [[2npd]], [[2npe]], [[2npg]], [[2npj]], [[2npk]], [[1u77]], [[3c1g]] – EcAmCh – Escherichia coli
**[[1u77]], [[1u7c]], [[1u7g]], [[1xqe]], [[1xqf]], [[2nmr]], [[2nop]], [[2now]], [[2npc]], [[2npd]], [[2npe]], [[2npg]], [[2npj]], [[2npk]], [[1u77]], [[3c1g]] – EcAmCh – Escherichia coli
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**[[3b9w]], [[3b9y]], [[3bhs]] – AmCh – Nitrosomonas europaea
**[[3b9w]], [[3b9y]], [[3bhs]] – AmCh – Nitrosomonas europaea
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MscL and MscS
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*MscL and MscS
**[[3hzq]] – MscL – Staphylococcus aureus
**[[3hzq]] – MscL – Staphylococcus aureus
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**[[9bgt]], [[9bgu]] – TcMscS (mutant) – Cryo EM<br />
**[[9bgt]], [[9bgu]] – TcMscS (mutant) – Cryo EM<br />
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Chloride channel or H(+)/Cl(-) exchange transporter ClcA or human proton-activated chloride channel PAC or CLIC
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*Chloride channel or H(+)/Cl(-) exchange transporter ClcA or human proton-activated chloride channel PAC or CLIC
**[[1rk4]], [[3swl]], [[7f8r]] - hClCh protein 1
**[[1rk4]], [[3swl]], [[7f8r]] - hClCh protein 1
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*CAMP-dependent chloride channel or cystic fibrosis transmembrane conductance regulator see CFTR in [[ABC transporter 3D structures]]
*CAMP-dependent chloride channel or cystic fibrosis transmembrane conductance regulator see CFTR in [[ABC transporter 3D structures]]
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+
*Anion Channel (Outer mitochondrial membrane protein porin 1)
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Anion Channel (Outer mitochondrial membrane protein porin 1)
+
**[[2jk4]], [[2k4t]], [[5jdn]], [[5xdo]], [[5xdp]], [[6g6u]], [[6g73]] – hVDAC1
**[[2jk4]], [[2k4t]], [[5jdn]], [[5xdo]], [[5xdp]], [[6g6u]], [[6g73]] – hVDAC1
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**[[9jvq]] – yVDAC1– Cryo EM<br />
**[[9jvq]] – yVDAC1– Cryo EM<br />
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Ligand-gated ion channel
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*Ligand-gated ion channel
**[[5osa]], [[5osb]] – mGLIC + GABAAR <br />
**[[5osa]], [[5osb]] – mGLIC + GABAAR <br />
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**[[2yks]], [[3uq4]], [[3uq5]], [[3uq7]], [[4twh]], [[5hej]], [[5heo]], [[5heu]], [[5hew]] – EchELIC (mutant)
**[[2yks]], [[3uq4]], [[3uq5]], [[3uq7]], [[4twh]], [[5hej]], [[5heo]], [[5heu]], [[5hew]] – EchELIC (mutant)
**[[6v03]], [[6v0b]], [[8d63]], [[8d64]], [[8d65]], [[8f35]], [[8twz]], [[9ngf]], [[9ngg]], [[9ngq]], [[9ngr]], [[9ngs]] - EchELIC – Cryo EM<br />
**[[6v03]], [[6v0b]], [[8d63]], [[8d64]], [[8d65]], [[8f35]], [[8twz]], [[9ngf]], [[9ngg]], [[9ngq]], [[9ngr]], [[9ngs]] - EchELIC – Cryo EM<br />
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**[[8d66]], [[8d67]], [[8d68]] – EchELIC3 (mutant) – Cryo EM<br />
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**[[8d66]], [[8d67]], [[8vuw]] – EchELIC3 (mutant) – Cryo EM<br />
**[[3rqw]] - EchELIC + acetylcholine<br />
**[[3rqw]] - EchELIC + acetylcholine<br />
**[[5sxu]] - EchELIC + bromoethanol<br />
**[[5sxu]] - EchELIC + bromoethanol<br />
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**[[3eam]], [[3ehz]], [[4hfi]], [[4il4]], [[4ilc]], [[4npp]], [[4npq]], [[4qh1]], [[4qh4]], [[4qh5]], [[4zzc]], [[6f16]], [[6f7a]], [[6hzw]] – GvGLIC - Gloeobacter violaceus<br />
**[[3eam]], [[3ehz]], [[4hfi]], [[4il4]], [[4ilc]], [[4npp]], [[4npq]], [[4qh1]], [[4qh4]], [[4qh5]], [[4zzc]], [[6f16]], [[6f7a]], [[6hzw]] – GvGLIC - Gloeobacter violaceus<br />
**[[6zgd]], [[6zgj]], [[6zgk]], [[8atg]], [[8i42]], [[8jj3]], [[8wcr]] – GvGLIC – Cryo EM<br />
**[[6zgd]], [[6zgj]], [[6zgk]], [[8atg]], [[8i42]], [[8jj3]], [[8wcr]] – GvGLIC – Cryo EM<br />
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**[[3ei0]], [[3tls]], [[3tlt]], [[3tlu]], [[3tlv]], [[3tlw]], [[3uu3]], [[3uu4]], [[3uu5]], [[3uu6]], [[3uu8]], [[3uub]], [[3lsv]], [[4hfb]], [[4il9]], [[4ila]], [[4ilb]], [[4ire]], [[4lmj]], [[4lmk]], [[4lml]], [[4zzb]], [[5hcj]], [[5hcm]], [[5heg]], [[5heh]], [[5iux]], [[5mzq]], [[5mzr]], [[5mzt]], [[5njy]], [[5nkj]], [[5v6n]], [[5v6o]], [[6emx]], [[6f0i]], [[6f0j]], [[6f0m]], [[6f0n]], [[6f0r]], [[6f0u]], [[6f0v]], [[6f0z]], [[6f10]], [[6f11]], [[6f012], [[6f13]], [[6f15]], [[6hy5]], [[6hy9]], [[6hya]], [[6hyr]], [[6hyv]], [[6hyw]], [[6hyx]], [[6hyz]], [[6hz0]], [[6hz1]], [[6hz3]], [[6i08]] – GvGLIC (mutant)
+
**[[3ei0]], [[3tls]], [[3tlt]], [[3tlu]], [[3tlv]], [[3tlw]], [[3uu3]], [[3uu4]], [[3uu5]], [[3uu6]], [[3uu8]], [[3uub]], [[3lsv]], [[4hfb]], [[4il9]], [[4ila]], [[4ilb]], [[4ire]], [[4lmj]], [[4lmk]], [[4lml]], [[4zzb]], [[5hcj]], [[5hcm]], [[5heg]], [[5heh]], [[5iux]], [[5mzq]], [[5mzr]], [[5mzt]], [[5njy]], [[5nkj]], [[5v6n]], [[5v6o]], [[6emx]], [[6f0i]], [[6f0j]], [[6f0m]], [[6f0n]], [[6f0r]], [[6f0u]], [[6f0v]], [[6f0z]], [[6f10]], [[6f11]], [[6f12]], [[6f13]], [[6f15]], [[6hy5]], [[6hy9]], [[6hya]], [[6hyr]], [[6hyv]], [[6hyw]], [[6hyx]], [[6hyz]], [[6hz0]], [[6hz1]], [[6hz3]], [[6i08]] – GvGLIC (mutant)
**[[3igq]] – GvGLIC N-terminal
**[[3igq]] – GvGLIC N-terminal
**[[2xq3]], [[2xq4]], [[2xq5]], [[2xq6]], [[2xq7]], [[2xq8]], [[2xqa]] – GvGLIC+inhibitor
**[[2xq3]], [[2xq4]], [[2xq5]], [[2xq6]], [[2xq7]], [[2xq8]], [[2xqa]] – GvGLIC+inhibitor
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**[[4hfd]], [[5mvm]], [[5mvn]], [[5muo]], [[5mur]] – GvGLIC (mutant) + general anaesthetic<br />
**[[4hfd]], [[5mvm]], [[5mvn]], [[5muo]], [[5mur]] – GvGLIC (mutant) + general anaesthetic<br />
**[[4hfc]], [[4hfe]] - GvGLIC (mutant) + alcohol<br />
**[[4hfc]], [[4hfe]] - GvGLIC (mutant) + alcohol<br />
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**[[5j0z]] - GvGLIC + choline derivative<br />
**[[5j0z]] - GvGLIC + choline derivative<br />
**[[5l47]], [[5l4e]], [[5l4h]] - GvGLIC + barbiturate<br />
**[[5l47]], [[5l4e]], [[5l4h]] - GvGLIC + barbiturate<br />
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**[[7q3h]], [[9evb]], [[9ftj]] – DeCLIC – Cryo EM<br />
**[[7q3h]], [[9evb]], [[9ftj]] – DeCLIC – Cryo EM<br />
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Cyclic Nucleotide-Gated channel
+
*Cyclic nucleotide-gated channel
**[[7lg1]] – hCNGA1 (mutant) – Cryo EM<br />
**[[7lg1]] – hCNGA1 (mutant) – Cryo EM<br />
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*Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
*Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
- 
**[[5u6o]], [[5u6p]], [[6uqf]], [[6uqg]] – hCNGC 1 – Cryo EM<br />
**[[5u6o]], [[5u6p]], [[6uqf]], [[6uqg]] – hCNGC 1 – Cryo EM<br />
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**[[5khg]], [[5khh]], [[5khi]], [[5khj]], [[5khk]] – mCNGC 2 ligand-binding domain + nucleotide<br />
**[[5khg]], [[5khh]], [[5khi]], [[5khj]], [[5khk]] – mCNGC 2 ligand-binding domain + nucleotide<br />
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Acid sensing ion channel
+
*Acid sensing ion channel
**[[6l6i]], [[6l6n]], [[6l6p]] – hASC <br />
**[[6l6i]], [[6l6n]], [[6l6p]] – hASC <br />
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**[[6x9h]] – cASC + modulator<br />
**[[6x9h]] – cASC + modulator<br />
-
ATP-Gated P2X channel (AGC) or P2X purinoceptor
+
*ATP-Gated P2X channel (AGC) or P2X purinoceptor
**[[5svj]], [[5svs]], [[5svt]] – hAGC P2X3 <br />
**[[5svj]], [[5svs]], [[5svt]] – hAGC P2X3 <br />
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**[[5wzy]] – zeAGC P2X4 + CTP<br />
**[[5wzy]] – zeAGC P2X4 + CTP<br />
-
Proton channel or matrix protein 2
+
*Proton channel or matrix protein 2
**[[2kj1]], [[2l0j]] - IVproton channel cytoplasmic domain – Influenza virus - NMR
**[[2kj1]], [[2l0j]] - IVproton channel cytoplasmic domain – Influenza virus - NMR
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**[[8bdz]], [[8ber]] - proton channel M2 – Hepatitis virus – Cryo EM<br />
**[[8bdz]], [[8ber]] - proton channel M2 – Hepatitis virus – Cryo EM<br />
-
Voltage-gated hydrogen channel (VGHC)
+
*Voltage-gated hydrogen channel (VGHC)
**[[3a2a]] – hVGHC C-terminal – NMR
**[[3a2a]] – hVGHC C-terminal – NMR
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**[[2eta]], [[2etb]], [[2etc]] – raTRPV2 ankyrin repeat domain <br />
**[[2eta]], [[2etb]], [[2etc]] – raTRPV2 ankyrin repeat domain <br />
**[[6bo4]], [[6bo5]], [[6u84]], [[6u86]] – raTRPV2 – Cryo EM<br />
**[[6bo4]], [[6bo5]], [[6u84]], [[6u86]] – raTRPV2 – Cryo EM<br />
-
**[[6wkn]], [[7n0m]], [[7n0n]], [[7t37]], [[7t38]], [[7zjh]], [[8fx8]], [[8fxg]], [[8slx]], [[8sly]] – raTRPV2 + cannabidiol – Cryo EM<br />
+
**[[6wkn]], [[7n0m]], [[7n0n]], [[7t37]], [[7t38]], [[7zjh]], [[8slx]], [[8sly]] – raTRPV2 + cannabidiol – Cryo EM<br />
**[[6u88]], [[6u8a]] – rTRPV2 + cannabidiol – Cryo EM<br />
**[[6u88]], [[6u8a]] – rTRPV2 + cannabidiol – Cryo EM<br />
**[[6bwm]] – rTRPV2 <br />
**[[6bwm]] – rTRPV2 <br />

Current revision

3D structures of ion channels

Updated on 08-October-2025


Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky

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