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9hur

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Current revision (07:34, 19 November 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9hur is ON HOLD until Paper Publication
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==Crystal structure of Tetraspanin CD63mutant Large Extracellular Loop (LEL) in complex with sybody LA4==
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<StructureSection load='9hur' size='340' side='right'caption='[[9hur]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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Authors: Nagarathinam, K., Krey, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9hur]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HUR FirstGlance]. <br>
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Description: Crystal structure of Tetraspanin CD63mutant Large Extracellular Loop (LEL) in complex with sybody LA4
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Krey, T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hur OCA], [https://pdbe.org/9hur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hur RCSB], [https://www.ebi.ac.uk/pdbsum/9hur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hur ProSAT]</span></td></tr>
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[[Category: Nagarathinam, K]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD63_HUMAN CD63_HUMAN] Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.<ref>PMID:16917503</ref> <ref>PMID:21803846</ref> <ref>PMID:21962903</ref> <ref>PMID:23632027</ref> <ref>PMID:24635319</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Krey T]]
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[[Category: Nagarathinam K]]

Current revision

Crystal structure of Tetraspanin CD63mutant Large Extracellular Loop (LEL) in complex with sybody LA4

PDB ID 9hur

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