1zzw

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(New page: 200px<br /> <applet load="1zzw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zzw, resolution 1.6&Aring;" /> '''Crystal Structure of...)
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[[Image:1zzw.gif|left|200px]]<br />
 
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<applet load="1zzw" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1zzw, resolution 1.6&Aring;" />
 
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'''Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5'''<br />
 
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==Overview==
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==Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5==
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MAP kinase phosphatase 5 (MKP5) is a member of the mitogen-activated, protein kinase phosphatase (MKP) family and selectively dephosphorylates, JNK and p38. We have determined the crystal structure of the catalytic, domain of human MKP5 (MKP5-C) to 1.6 A. In previously reported MKP-C, structures, the residues that constitute the active site are seriously, deviated from the active conformation of protein tyrosine phosphatases, (PTPs), which are accompanied by low catalytic activity. High activities, of MKPs are achieved by binding their cognate substrates, representing, substrate-induced activation. However, the MKP5-C structure adopts an, active conformation of PTP even in the absence of its substrate binding, which is consistent with the previous results that MKP5 solely possesses, the intrinsic activity. Further, we identify a sequence motif common to, the members of MKPs having low catalytic activity by comparing structures, and sequences of other MKPs. Our structural information provides an, explanation of constitutive activity of MKP5 as well as the structural, insight into substrate-induced activation occurred in other MKPs.
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<StructureSection load='1zzw' size='340' side='right'caption='[[1zzw]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zzw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZZW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zzw OCA], [https://pdbe.org/1zzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zzw RCSB], [https://www.ebi.ac.uk/pdbsum/1zzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zzw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DUS10_HUMAN DUS10_HUMAN] Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.<ref>PMID:22375048</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/1zzw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zzw ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1ZZW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and EDO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZZW OCA].
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*[[MAP kinase phosphatase|MAP kinase phosphatase]]
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== References ==
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==Reference==
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<references/>
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Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase., Jeong DG, Yoon TS, Kim JH, Shim MY, Jung SK, Son JH, Ryu SE, Kim SJ, J Mol Biol. 2006 Jul 28;360(5):946-55. Epub 2006 Jun 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16806267 16806267]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Jeong, D.G.]]
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[[Category: Jeong DG]]
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[[Category: Jeong, S.K.]]
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[[Category: Jeong SK]]
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[[Category: Kim, J.H.]]
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[[Category: Kim JH]]
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[[Category: Kim, S.J.]]
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[[Category: Kim SJ]]
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[[Category: Ryu, S.E.]]
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[[Category: Ryu SE]]
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[[Category: Shim, M.Y.]]
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[[Category: Shim MY]]
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[[Category: Son, J.H.]]
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[[Category: Son JH]]
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[[Category: Yoon, T.S.]]
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[[Category: Yoon TS]]
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[[Category: EDO]]
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[[Category: SO4]]
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[[Category: mkp]]
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[[Category: phosphatase]]
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[[Category: ptp]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:43:40 2007''
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Current revision

Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5

PDB ID 1zzw

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