2a14

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="2a14" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a14, resolution 1.70&Aring;" /> '''Crystal Structure o...)
Current revision (07:17, 23 August 2023) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2a14.gif|left|200px]]<br />
 
-
<applet load="2a14" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2a14, resolution 1.70&Aring;" />
 
-
'''Crystal Structure of Human Indolethylamine N-methyltransferase with SAH'''<br />
 
-
==About this Structure==
+
==Crystal Structure of Human Indolethylamine N-methyltransferase with SAH==
-
2A14 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and SAH as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Amine_N-methyltransferase Amine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.49 2.1.1.49] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2A14 OCA].
+
<StructureSection load='2a14' size='340' side='right'caption='[[2a14]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
[[Category: Amine N-methyltransferase]]
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2a14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A14 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a14 OCA], [https://pdbe.org/2a14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a14 RCSB], [https://www.ebi.ac.uk/pdbsum/2a14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a14 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/INMT_HUMAN INMT_HUMAN] Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.<ref>PMID:10552930</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/2a14_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a14 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C.H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Bochkarev A]]
-
[[Category: Dong, A.]]
+
[[Category: Dong A]]
-
[[Category: Edwards, A.M.]]
+
[[Category: Edwards AM]]
-
[[Category: Loppnau, P.]]
+
[[Category: Loppnau P]]
-
[[Category: Plotnikov, A.N.]]
+
[[Category: Plotnikov AN]]
-
[[Category: SGC, Structural.Genomics.Consortium.]]
+
[[Category: Sundstrom M]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Wu H]]
-
[[Category: Wu, H.]]
+
[[Category: Zeng H]]
-
[[Category: Zeng, H.]]
+
-
[[Category: SAH]]
+
-
[[Category: SO4]]
+
-
[[Category: inmt]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomics]]
+
-
[[Category: structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:44:20 2007''
+

Current revision

Crystal Structure of Human Indolethylamine N-methyltransferase with SAH

PDB ID 2a14

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2a14"
Personal tools