9ko6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==A local Cryo_EM structure of CCR7 complex with CCL19== | |
| - | + | <StructureSection load='9ko6' size='340' side='right'caption='[[9ko6]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ko6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KO6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ko6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ko6 OCA], [https://pdbe.org/9ko6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ko6 RCSB], [https://www.ebi.ac.uk/pdbsum/9ko6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ko6 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CCL19_HUMAN CCL19_HUMAN] May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.<ref>PMID:9498785</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cao Y]] | ||
| + | [[Category: Duan J]] | ||
| + | [[Category: Yuan Q]] | ||
Current revision
A local Cryo_EM structure of CCR7 complex with CCL19
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Categories: Homo sapiens | Large Structures | Cao Y | Duan J | Yuan Q
