Image:9ovr.pdb

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	Date/Time	User	Dimensions	File size	Comment
(current)	18:32, 30 November 2025	Mousumi Kandangkel (Talk \| contribs)		872 KB	Description: This view displays the complete homodimeric architecture of human NBCn1 (PDB: 9OVR) as resolved by cryo-EM. The structure shows two identical protein chains (monomers) arranged side-by-side, with Chain A colored cyan and Chain B colored magen

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-Description:
-This view displays the complete homodimeric architecture of human NBCn1 (PDB: 9OVR) as resolved by cryo-EM. The structure shows two identical protein chains (monomers) arranged side-by-side, with Chain A colored cyan and Chain B colored magenta.
-Key Structural Features:
-Homodimeric Organization: NBCn1 functions as a dimer, which provides stability and may regulate transport activity
-Chain Symmetry: Both monomers adopt identical folds with 14 transmembrane helices each
-Membrane Spanning: The elongated shape reflects the protein's orientation across the lipid bilayer
-Functional Units: Each monomer contains independent transport machinery while the dimer interface likely plays a regulatory role
-Biological Significance:
-The dimeric arrangement is characteristic of SLC4 family transporters and may facilitate coordinated pH regulation. This quaternary structure represents the functional form of NBCn1 as it exists in the plasma membrane of breast cancer cells, where it maintains intracellular alkalinity against the acidic tumor microenvironment.