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1x22

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[[Image:1x22.gif|left|200px]]
 
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==Solution structure of a novel moricin analogue, an antibacterial peptide from a lepidopteran insect, Spodoptera litura==
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The line below this paragraph, containing "STRUCTURE_1x22", creates the "Structure Box" on the page.
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<StructureSection load='1x22' size='340' side='right'caption='[[1x22]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x22]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Spodoptera_litura Spodoptera litura]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X22 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x22 OCA], [https://pdbe.org/1x22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x22 RCSB], [https://www.ebi.ac.uk/pdbsum/1x22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x22 ProSAT]</span></td></tr>
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{{STRUCTURE_1x22| PDB=1x22 | SCENE= }}
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</table>
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== Function ==
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'''Solution structure of a novel moricin analogue, an antibacterial peptide from a lepidopteran insect, Spodoptera litura'''
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[https://www.uniprot.org/uniprot/Q7YZB4_SPOLT Q7YZB4_SPOLT]
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__TOC__
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</StructureSection>
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==Overview==
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[[Category: Large Structures]]
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An antibacterial peptide was isolated from a lepidopteran insect, Spodoptera litura. The molecular mass of this peptide was determined to be 4489.55 by matrix assisted laser desorption/ionization-time of flight mass (MALDI-TOF MS) spectrometry. The peptide consists of 42 amino acids and the sequence has 69-98% identity to those of moricin-related peptides, antibacterial peptides from lepidopetran insects. Thus, the peptide was designated S. litura (Sl) moricin. Sl moricin showed a broad antibacterial spectrum against Gram-positive and negative bacteria. Sl moricin gene was inducible by bacterial injection and expressed tissue-specifically in the fat body and hemocytes. Furthermore, the solution structure of Sl moricin was determined by two-dimensional (2D) 1H-nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-simulated annealing calculation. The tertiary structure revealed a long alpha-helix containing eight turns along nearly the full length of the peptide like that of moricin, confirming that Sl moricin is a new moricin-like antibacterial peptide. These results suggest that moricin is present not only in B. mori but also in other lepidopteran insects forming a gene family.
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[[Category: Spodoptera litura]]
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[[Category: Asaoka A]]
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==About this Structure==
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[[Category: Hemmi H]]
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1X22 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X22 OCA].
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[[Category: Minami M]]
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[[Category: Oizumi Y]]
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==Reference==
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[[Category: Yamakawa M]]
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Isolation, gene expression and solution structure of a novel moricin analogue, antibacterial peptide from a lepidopteran insect, Spodoptera litura., Oizumi Y, Hemmi H, Minami M, Asaoka A, Yamakawa M, Biochim Biophys Acta. 2005 Aug 31;1752(1):83-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16115804 16115804]
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[[Category: Single protein]]
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[[Category: Asaoka, A.]]
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[[Category: Hemmi, H.]]
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[[Category: Minami, M.]]
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[[Category: Oizumi, Y.]]
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[[Category: Yamakawa, M.]]
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[[Category: Antibacterial peptide]]
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[[Category: Gene expression]]
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[[Category: Insect immunity]]
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[[Category: Moricin]]
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[[Category: Nmr]]
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[[Category: Purification]]
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[[Category: Solution structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:25:48 2008''
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Current revision

Solution structure of a novel moricin analogue, an antibacterial peptide from a lepidopteran insect, Spodoptera litura

PDB ID 1x22

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