1x51

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[[Image:1x51.gif|left|200px]]
 
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==Solution structure of the NUDIX domain from human A/G-specific adenine DNA glycosylase alpha-3 splice isoform==
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The line below this paragraph, containing "STRUCTURE_1x51", creates the "Structure Box" on the page.
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<StructureSection load='1x51' size='340' side='right'caption='[[1x51]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x51]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X51 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x51 OCA], [https://pdbe.org/1x51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x51 RCSB], [https://www.ebi.ac.uk/pdbsum/1x51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x51 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x51 TOPSAN]</span></td></tr>
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{{STRUCTURE_1x51| PDB=1x51 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MUTYH_HUMAN MUTYH_HUMAN] Defects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) [MIM:[https://omim.org/entry/608456 608456]. A condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.<ref>PMID:11818965</ref> <ref>PMID:12853198</ref> <ref>PMID:12606733</ref> <ref>PMID:15366000</ref> <ref>PMID:18091433</ref> <ref>PMID:19953527</ref> Defects in MUTYH are a cause of gastric cancer (GASC) [MIM:[https://omim.org/entry/613659 613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.<ref>PMID:15273732</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MUTYH_HUMAN MUTYH_HUMAN] Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.<ref>PMID:10684930</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x51_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x51 ConSurf].
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<div style="clear:both"></div>
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'''Solution structure of the NUDIX domain from human A/G-specific adenine DNA glycosylase alpha-3 splice isoform'''
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==See Also==
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: Adenomas, multiple colorectal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604933 604933]], Colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604933 604933]], Gastric cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604933 604933]]
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__TOC__
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</StructureSection>
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==About this Structure==
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1X51 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X51 OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tomizawa T]]
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[[Category: Tomizawa, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Alpha-3 isoform]]
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[[Category: Dna repair]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Nudix domain]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:33:03 2008''
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Current revision

Solution structure of the NUDIX domain from human A/G-specific adenine DNA glycosylase alpha-3 splice isoform

PDB ID 1x51

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OCA

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