1xcu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:49, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1xcu.gif|left|200px]]
 
-
<!--
+
==oligonucleotid/drug complex==
-
The line below this paragraph, containing "STRUCTURE_1xcu", creates the "Structure Box" on the page.
+
<StructureSection load='1xcu' size='340' side='right'caption='[[1xcu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1xcu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XCU FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AN9:1,5-BIS[3-(DIETHYLAMINO)PROPIONAMIDO]ANTHRACENE-9,10-DIONE'>AN9</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
{{STRUCTURE_1xcu| PDB=1xcu | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcu OCA], [https://pdbe.org/1xcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xcu RCSB], [https://www.ebi.ac.uk/pdbsum/1xcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xcu ProSAT]</span></td></tr>
-
 
+
</table>
-
'''oligonucleotid/drug complex'''
+
__TOC__
-
 
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
==Overview==
+
[[Category: Murshudov GN]]
-
The crystal structures of the hexamer duplex d(CGTACG)(2) complexed with the intercalating anthraquinone derivative 1,5-bis[3-(diethylamino)propionamido]anthracene-9,10-dione and the acridine derivative 9-acridinyl tetralysine have been solved at 2.0- and 1.4-A resolution, respectively. In both cases, the drugs adopt multiple orientations within a large DNA cavity constituted by two groups of four approximately coplanar bases. Cations play a pivotal role in the crystal structure. Both complexes crystallise in the presence of Co(2+), Ba(2+) and Na(+) ions. They reveal at least two different types of coordination environments: (1) specific sites for Co(2+) interacting with N7 of guanine; (2) a central ionic site formed by four phosphate groups, which can be occupied by different ions. One more ionic site that is not always occupied by ions is also visible in the electron density map. All of them play a role in the crystal structure.
+
[[Category: Steiner RA]]
-
 
+
[[Category: Subirana JA]]
-
==About this Structure==
+
[[Category: Valls N]]
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCU OCA].
+
[[Category: Wright G]]
-
 
+
-
==Reference==
+
-
Variable role of ions in two drug intercalation complexes of DNA., Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA, J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15926069 15926069]
+
-
[[Category: Murshudov, G N.]]
+
-
[[Category: Steiner, R A.]]
+
-
[[Category: Subirana, J A.]]
+
-
[[Category: Valls, N.]]
+
-
[[Category: Wright, G.]]
+
-
[[Category: Anthraquinone]]
+
-
[[Category: Co2+]]
+
-
[[Category: Drug-dna complex]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:51:59 2008''
+

Current revision

oligonucleotid/drug complex

PDB ID 1xcu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xcu"
Personal tools