2aux

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(New page: 200px<br /> <applet load="2aux" size="450" color="white" frame="true" align="right" spinBox="true" caption="2aux, resolution 2.4&Aring;" /> '''Cathepsin K complexe...)
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[[Image:2aux.gif|left|200px]]<br />
 
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<applet load="2aux" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2aux, resolution 2.4&Aring;" />
 
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'''Cathepsin K complexed with a semicarbazone inhibitor'''<br />
 
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==Overview==
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==Cathepsin K complexed with a semicarbazone inhibitor==
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Starting from potent aldehyde inhibitors with poor drug properties, derivatization to semicarbazones led to the identification of a series of, semicarbazone-based cathepsin K inhibitors with greater solubility and, better pharmacokinetic profiles than their parent aldehydes. Furthermore, a representative semicarbazone inhibitor attenuated bone resorption in an, ex vivo rat calvarial bone resorption model. However, based on enzyme, inhibition comparisons at neutral pH, semicarbazone hydrolysis rates, and, 13C NMR experiments, these semicarbazones probably function as prodrugs of, aldehydes.
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<StructureSection load='2aux' size='340' side='right'caption='[[2aux]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2aux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CT1:(1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATE'>CT1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aux OCA], [https://pdbe.org/2aux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aux RCSB], [https://www.ebi.ac.uk/pdbsum/2aux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aux ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2aux_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aux ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Starting from potent aldehyde inhibitors with poor drug properties, derivatization to semicarbazones led to the identification of a series of semicarbazone-based cathepsin K inhibitors with greater solubility and better pharmacokinetic profiles than their parent aldehydes. Furthermore, a representative semicarbazone inhibitor attenuated bone resorption in an ex vivo rat calvarial bone resorption model. However, based on enzyme inhibition comparisons at neutral pH, semicarbazone hydrolysis rates, and 13C NMR experiments, these semicarbazones probably function as prodrugs of aldehydes.
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==Disease==
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Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?,Adkison KK, Barrett DG, Deaton DN, Gampe RT, Hassell AM, Long ST, McFadyen RB, Miller AB, Miller LR, Payne JA, Shewchuk LM, Wells-Knecht KJ, Willard DH Jr, Wright LL Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. Epub 2005 Nov 15. PMID:16290936<ref>PMID:16290936</ref>
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Known disease associated with this structure: Pycnodysostosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601105 601105]]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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2AUX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CT1 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AUX OCA].
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</div>
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<div class="pdbe-citations 2aux" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?, Adkison KK, Barrett DG, Deaton DN, Gampe RT, Hassell AM, Long ST, McFadyen RB, Miller AB, Miller LR, Payne JA, Shewchuk LM, Wells-Knecht KJ, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. Epub 2005 Nov 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16290936 16290936]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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[[Category: Cathepsin K]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Adkison, K.K.]]
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[[Category: Adkison KK]]
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[[Category: Barrett, D.G.]]
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[[Category: Barrett DG]]
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[[Category: Deaton, D.N.]]
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[[Category: Deaton DN]]
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[[Category: Gampe, R.T.]]
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[[Category: Gampe RT]]
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[[Category: Hassell, A.M.]]
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[[Category: Hassell AM]]
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[[Category: Long, S.T.]]
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[[Category: Long ST]]
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[[Category: McFadyen, R.B.]]
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[[Category: McFadyen RB]]
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[[Category: Miller, A.B.]]
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[[Category: Miller AB]]
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[[Category: Miller, L.R.]]
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[[Category: Miller LR]]
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[[Category: Shewchuk, L.M.]]
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[[Category: Shewchuk LM]]
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[[Category: CT1]]
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[[Category: catk]]
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[[Category: cysteine protease]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:54:54 2007''
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Current revision

Cathepsin K complexed with a semicarbazone inhibitor

PDB ID 2aux

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