1xy2
From Proteopedia
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| - | [[Image:1xy2.jpg|left|200px]] | ||
| - | + | ==CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING== | |
| - | + | <StructureSection load='1xy2' size='340' side='right'caption='[[1xy2]], [[Resolution|resolution]] 1.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1xy2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XY2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPR:2-MERCAPTO-PROPION+ALDEHYDE'>MPR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy2 OCA], [https://pdbe.org/1xy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xy2 RCSB], [https://www.ebi.ac.uk/pdbsum/1xy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy2 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | ''' | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/NEU1_BOVIN NEU1_BOVIN] Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. | |
| - | + | <div style="background-color:#fffaf0;"> | |
| - | == | + | == Publication Abstract from PubMed == |
Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation. | Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation. | ||
| - | + | Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.,Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY, Husain J, Cooper S, Blundell TL, Hruby VJ, et al. Science. 1986 May 2;232(4750):633-6. PMID:3008332<ref>PMID:3008332</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: Blundell | + | <div class="pdbe-citations 1xy2" style="background-color:#fffaf0;"></div> |
| - | [[Category: Cooper | + | == References == |
| - | [[Category: Pitts | + | <references/> |
| - | [[Category: Tickle | + | __TOC__ |
| - | [[Category: Wood | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Blundell TL]] | |
| + | [[Category: Cooper S]] | ||
| + | [[Category: Pitts JE]] | ||
| + | [[Category: Tickle IJ]] | ||
| + | [[Category: Wood SP]] | ||
Current revision
CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING
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