1y0h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:54, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1y0h.gif|left|200px]]
 
-
<!--
+
==Structure of Rv0793 from Mycobacterium tuberculosis==
-
The line below this paragraph, containing "STRUCTURE_1y0h", creates the "Structure Box" on the page.
+
<StructureSection load='1y0h' size='340' side='right'caption='[[1y0h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1y0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y0H FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-
{{STRUCTURE_1y0h| PDB=1y0h | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0h OCA], [https://pdbe.org/1y0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0h RCSB], [https://www.ebi.ac.uk/pdbsum/1y0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0h ProSAT], [https://www.topsan.org/Proteins/TBSGC/1y0h TOPSAN]</span></td></tr>
-
 
+
</table>
-
'''Structure of Rv0793 from Mycobacterium tuberculosis'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/Y0793_MYCTU Y0793_MYCTU] Putative monooygenase that might be involved in antibiotic biosynthesis, or may act as reactive oxygen species scavenger that could help in evading host defenses.
-
 
+
== Evolutionary Conservation ==
-
==Overview==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
Mycobacterium tuberculosis infects millions worldwide. The Structural Genomics Consortium for M. tuberculosis has targeted all genes from this bacterium in hopes of discovering and developing new therapeutic agents. Open reading frame Rv0793 from M. tuberculosis was annotated with an unknown function. The 3-dimensional structure of Rv0793 has been solved to 1.6 A resolution. Its structure is very similar to that of Streptomyces coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of polyketide antibiotics in the absence of a cofactor. It is also similar to the recently solved structure of YgiN, a quinol monooxygenase from Escherichia coli. In addition, the structure of Rv0793 is similar to several structures of other proteins with unknown function. These latter structures have been determined recently as a result of structural genomic projects for various bacterial species. In M. tuberculosis, Rv0793 and its homologs may represent a class of monooygenases acting as reactive oxygen species scavengers that are essential for evading host defenses. Since the most prevalent mode of attack by the host defense on M. tuberculosis is by reactive oxygen species and reactive nitrogen species, Rv0793 may provide a novel target to combat infection by M. tuberculosis.
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y0h_consurf.spt"</scriptWhenChecked>
-
1Y0H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0H OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==Reference==
+
</jmolCheckbox>
-
The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis., Lemieux MJ, Ference C, Cherney MM, Wang M, Garen C, James MN, J Struct Funct Genomics. 2005 Dec;6(4):245-57. Epub 2006 Feb 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16496224 16496224]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y0h ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
-
[[Category: Single protein]]
+
[[Category: Cherney MM]]
-
[[Category: Cherney, M M.]]
+
[[Category: Ference C]]
-
[[Category: Ference, C.]]
+
[[Category: Garen C]]
-
[[Category: Garen, C.]]
+
[[Category: James MN]]
-
[[Category: James, M N.]]
+
[[Category: Lemieux MJ]]
-
[[Category: Lemieux, M J.]]
+
[[Category: Wang M]]
-
[[Category: TBSGC, TB Structural Genomics Consortium.]]
+
-
[[Category: Wang, M.]]
+
-
[[Category: Alpha+beta sandwich with antiparallel beta-sheet]]
+
-
[[Category: Ferredoxin-like fold]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Tb structural genomics consortium]]
+
-
[[Category: Tbsgc]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:44:01 2008''
+

Current revision

Structure of Rv0793 from Mycobacterium tuberculosis

PDB ID 1y0h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1y0h"
Personal tools