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2c47
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2c47" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c47, resolution 2.40Å" /> '''STRUCTURE OF CASEIN...) |
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| - | [[Image:2c47.gif|left|200px]]<br /> | ||
| - | <applet load="2c47" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2c47, resolution 2.40Å" /> | ||
| - | '''STRUCTURE OF CASEIN KINASE 1 GAMMA 2'''<br /> | ||
| - | == | + | ==Structure of casein kinase 1 gamma 2== |
| - | + | <StructureSection load='2c47' size='340' side='right'caption='[[2c47]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[2c47]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C47 FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ID:(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL'>5ID</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c47 OCA], [https://pdbe.org/2c47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c47 RCSB], [https://www.ebi.ac.uk/pdbsum/2c47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c47 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/KC1G2_HUMAN KC1G2_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.<ref>PMID:15342122</ref> <ref>PMID:15077195</ref> <ref>PMID:18794808</ref> <ref>PMID:19005213</ref> | |
| - | [ | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | [ | + | <jmolCheckbox> |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c47_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c47 ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | [[ | + | |
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| - | [ | + | |
| - | [[ | + | |
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| - | + | ||
| - | + | ==See Also== | |
| + | *[[Casein kinase 3D structures|Casein kinase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Amos A]] | ||
| + | [[Category: Arrowsmith C]] | ||
| + | [[Category: Ball L]] | ||
| + | [[Category: Bullock A]] | ||
| + | [[Category: Bunkoczi G]] | ||
| + | [[Category: Das S]] | ||
| + | [[Category: Debreczeni J]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Eswaran J]] | ||
| + | [[Category: Fedorov O]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Rellos P]] | ||
| + | [[Category: Sobott F]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Turnbull A]] | ||
| + | [[Category: Ugochukwu E]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Structure of casein kinase 1 gamma 2
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Categories: Homo sapiens | Large Structures | Amos A | Arrowsmith C | Ball L | Bullock A | Bunkoczi G | Das S | Debreczeni J | Edwards A | Eswaran J | Fedorov O | Knapp S | Rellos P | Sobott F | Sundstrom M | Turnbull A | Ugochukwu E | Weigelt J | Von Delft F
