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1ysv

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[[Image:1ysv.gif|left|200px]]
 
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==Solution structure of the central region of the human GluR-B R/G pre-mRNA==
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The line below this paragraph, containing "STRUCTURE_1ysv", creates the "Structure Box" on the page.
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<StructureSection load='1ysv' size='340' side='right'caption='[[1ysv]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ysv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YSV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ysv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysv OCA], [https://pdbe.org/1ysv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ysv RCSB], [https://www.ebi.ac.uk/pdbsum/1ysv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysv ProSAT]</span></td></tr>
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{{STRUCTURE_1ysv| PDB=1ysv | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''Solution structure of the central region of the human GluR-B R/G pre-mRNA'''
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== Publication Abstract from PubMed ==
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==Overview==
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Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.
Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.
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==About this Structure==
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A novel RNA pentaloop fold involved in targeting ADAR2.,Stefl R, Allain FH RNA. 2005 May;11(5):592-7. PMID:15840813<ref>PMID:15840813</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15840813 15840813]
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</div>
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[[Category: Allain, F H.]]
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<div class="pdbe-citations 1ysv" style="background-color:#fffaf0;"></div>
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[[Category: Stefl, R.]]
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== References ==
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[[Category: Adar2]]
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<references/>
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[[Category: Nmr]]
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__TOC__
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[[Category: Pentaloop]]
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</StructureSection>
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[[Category: Rna]]
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[[Category: Homo sapiens]]
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[[Category: Rna editing]]
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[[Category: Large Structures]]
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[[Category: Stem-loop]]
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[[Category: Allain FH]]
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[[Category: Structure]]
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[[Category: Stefl R]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:44:38 2008''
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Current revision

Solution structure of the central region of the human GluR-B R/G pre-mRNA

PDB ID 1ysv

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