1z14

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[[Image:1z14.gif|left|200px]]
 
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==Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute Virus of Mice==
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The line below this paragraph, containing "STRUCTURE_1z14", creates the "Structure Box" on the page.
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<StructureSection load='1z14' size='340' side='right'caption='[[1z14]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Minute_virus_of_mice Minute virus of mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z14 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z14 OCA], [https://pdbe.org/1z14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z14 RCSB], [https://www.ebi.ac.uk/pdbsum/1z14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z14 ProSAT]</span></td></tr>
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{{STRUCTURE_1z14| PDB=1z14 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q84367_MUMIP Q84367_MUMIP]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z14_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z14 ConSurf].
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<div style="clear:both"></div>
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'''Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute Virus of Mice'''
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Two strains of the parvovirus minute virus of mice (MVM), the immunosuppressive (MVMi) and the prototype (MVMp) strains, display disparate in vitro tropism and in vivo pathogenicity. We report the crystal structures of MVMp virus-like particles (MVMp(b)) and native wild-type (wt) empty capsids (MVMp(e)), determined and refined to 3.25 and 3.75 A resolution, respectively, and their comparison to the structure of MVMi, also refined to 3.5 A resolution in this study. A comparison of the MVMp(b) and MVMp(e) capsids showed their structures to be the same, providing structural verification that some heterologously expressed parvovirus capsids are indistinguishable from wt capsids produced in host cells. The structures of MVMi and MVMp capsids were almost identical, but local surface conformational differences clustered from symmetry-related capsid proteins at three specific domains: (i) the icosahedral fivefold axis, (ii) the "shoulder" of the protrusion at the icosahedral threefold axis, and (iii) the area surrounding the depression at the icosahedral twofold axis. The latter two domains contain important determinants of MVM in vitro tropism (residues 317 and 321) and forward mutation residues (residues 399, 460, 553, and 558) conferring fibrotropism on MVMi. Furthermore, these structural differences between the MVM strains colocalize with tropism and pathogenicity determinants mapped for other autonomous parvovirus capsids, highlighting the importance of common parvovirus capsid regions in the control of virus-host interactions.
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[[Category: Large Structures]]
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==About this Structure==
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1Z14 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Minute_virus_of_mice Minute virus of mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z14 OCA].
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==Reference==
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Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice., Kontou M, Govindasamy L, Nam HJ, Bryant N, Llamas-Saiz AL, Foces-Foces C, Hernando E, Rubio MP, McKenna R, Almendral JM, Agbandje-McKenna M, J Virol. 2005 Sep;79(17):10931-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16103145 16103145]
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[[Category: Minute virus of mice]]
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[[Category: Single protein]]
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[[Category: Agbandje-McKenna, M.]]
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[[Category: Almendral, J M.]]
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[[Category: Bryant, N.]]
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[[Category: Foces-Foces, C.]]
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[[Category: Govindasamy, L.]]
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[[Category: Hernando, E.]]
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[[Category: Kontou, M.]]
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[[Category: Llamas-Saiz, A L.]]
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[[Category: McKenna, R.]]
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[[Category: Nam, H J.]]
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[[Category: Rubio, M P.]]
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[[Category: Icosahedral virus]]
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[[Category: Minute virus of mice]]
[[Category: Minute virus of mice]]
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[[Category: Prototype strain]]
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[[Category: Agbandje-McKenna M]]
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[[Category: X-ray crystallography]]
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[[Category: Almendral JM]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:03:38 2008''
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[[Category: Bryant N]]
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[[Category: Foces-Foces C]]
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[[Category: Govindasamy L]]
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[[Category: Hernando E]]
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[[Category: Kontou M]]
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[[Category: Llamas-Saiz AL]]
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[[Category: McKenna R]]
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[[Category: Nam HJ]]
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[[Category: Rubio MP]]

Current revision

Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute Virus of Mice

PDB ID 1z14

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