1z3y

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[[Image:1z3y.gif|left|200px]]
 
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==Structure of Gun4-1 from Thermosynechococcus elongatus==
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The line below this paragraph, containing "STRUCTURE_1z3y", creates the "Structure Box" on the page.
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<StructureSection load='1z3y' size='340' side='right'caption='[[1z3y]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosynechococcus_vestitus Thermosynechococcus vestitus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3y OCA], [https://pdbe.org/1z3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3y RCSB], [https://www.ebi.ac.uk/pdbsum/1z3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3y ProSAT]</span></td></tr>
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{{STRUCTURE_1z3y| PDB=1z3y | SCENE= }}
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</table>
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== Function ==
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'''Structure of Gun4-1 from Thermosynechococcus elongatus'''
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[https://www.uniprot.org/uniprot/Q8DIJ1_THEVB Q8DIJ1_THEVB]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Gun4 has been implicated in a developmental signaling pathway between the chloroplast and the nucleus involving magnesium protoporphyrin IX (MgP(IX)), the first dedicated intermediate in the chlorophyll biosynthetic pathway. Here we present the crystal structure of Thermosynechococcus elongatus Gun4 at 1.5 A, describe the binding affinities of Gun4 for substrate and product porphyrin molecules, and identify a likely (Mg)P(IX) binding site on the protein. Kinetic analyses show that Gun4 dramatically increases the efficiency of transformation of porphyrin substrate to metalloporphyrin product and that it also reduces the threshold Mg2+ concentration required for activity at low porphyrin concentration. Gun4 therefore controls magnesium chelatase at physiologically significant Mg2+ concentrations and likely acts as a molecular switch in vivo so that in its absence magnesium chelatase is inactive. This mechanism could allow Gun4 to mediate magnesium protoporphyrin levels both for chlorophyll biosynthesis and for signaling to the nucleus.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3y_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1Z3Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3Y OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3y ConSurf].
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Structural and biochemical characterization of Gun4 suggests a mechanism for its role in chlorophyll biosynthesis., Davison PA, Schubert HL, Reid JD, Iorg CD, Heroux A, Hill CP, Hunter CN, Biochemistry. 2005 May 31;44(21):7603-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15909975 15909975]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: Thermosynechococcus elongatus]]
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</StructureSection>
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[[Category: Davison, P A.]]
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[[Category: Large Structures]]
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[[Category: Hill, C P.]]
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[[Category: Thermosynechococcus vestitus]]
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[[Category: Hunter, C N.]]
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[[Category: Davison PA]]
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[[Category: Iorg, C D.]]
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[[Category: Hill CP]]
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[[Category: Reid, J D.]]
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[[Category: Hunter CN]]
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[[Category: Robinson, H.]]
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[[Category: Iorg CD]]
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[[Category: Schubert, H L.]]
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[[Category: Reid JD]]
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[[Category: Transferase activator]]
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[[Category: Robinson H]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:09:21 2008''
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[[Category: Schubert HL]]

Current revision

Structure of Gun4-1 from Thermosynechococcus elongatus

PDB ID 1z3y

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