2cp6

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(New page: 200px<br /> <applet load="2cp6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cp6" /> '''Solution structure of the 2nd CAP-Gly domai...)
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[[Image:2cp6.gif|left|200px]]<br />
 
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<applet load="2cp6" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cp6" />
 
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'''Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin'''<br />
 
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==About this Structure==
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==Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin==
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2CP6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CP6 OCA].
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<StructureSection load='2cp6' size='340' side='right'caption='[[2cp6]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2cp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CP6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cp6 OCA], [https://pdbe.org/2cp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cp6 RCSB], [https://www.ebi.ac.uk/pdbsum/2cp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cp6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cp6 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CLIP1_HUMAN CLIP1_HUMAN] Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.<ref>PMID:12433698</ref> <ref>PMID:17889670</ref> <ref>PMID:17563362</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cp6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cp6 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[[Category: Saito K]]
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[[Category: Saito, K.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: cytoskeleton associated protein]]
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[[Category: microtubule binding]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: restin]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:19:00 2007''
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Current revision

Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin

PDB ID 2cp6

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