1z58

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:02, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1z58.gif|left|200px]]
 
-
<!--
+
==Crystal structure of a complex of the ribosome large subunit with rapamycin==
-
The line below this paragraph, containing "STRUCTURE_1z58", creates the "Structure Box" on the page.
+
<StructureSection load='1z58' size='340' side='right'caption='[[1z58]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1z58]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z58 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
-
{{STRUCTURE_1z58| PDB=1z58 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z58 OCA], [https://pdbe.org/1z58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z58 RCSB], [https://www.ebi.ac.uk/pdbsum/1z58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z58 ProSAT]</span></td></tr>
 +
</table>
-
'''Crystal structure of a complex of the ribosome large subunit with rapamycin'''
+
==See Also==
-
 
+
*[[Ribosome 3D structures|Ribosome 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.
+
-
 
+
-
==About this Structure==
+
-
1Z58 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA].
+
-
 
+
-
==Reference==
+
-
A crevice adjoining the ribosome tunnel: hints for cotranslational folding., Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A, FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15943964 15943964]
+
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Amit, M.]]
+
[[Category: Amit M]]
-
[[Category: Baram, D.]]
+
[[Category: Baram D]]
-
[[Category: Bashan, A.]]
+
[[Category: Bashan A]]
-
[[Category: Berisio, R.]]
+
[[Category: Berisio R]]
-
[[Category: Harms, J.]]
+
[[Category: Harms J]]
-
[[Category: Yonath, A.]]
+
[[Category: Yonath A]]
-
[[Category: Polyketyde]]
+
-
[[Category: Ribosome]]
+
-
[[Category: Tunnel]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:11:22 2008''
+

Current revision

Crystal structure of a complex of the ribosome large subunit with rapamycin

PDB ID 1z58

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z58"
Personal tools