1z63

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:43, 21 November 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1z63.gif|left|200px]]
 
-
<!--
+
==Sulfolobus solfataricus SWI2/SNF2 ATPase core in complex with dsDNA==
-
The line below this paragraph, containing "STRUCTURE_1z63", creates the "Structure Box" on the page.
+
<StructureSection load='1z63' size='340' side='right'caption='[[1z63]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1z63]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z63 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
{{STRUCTURE_1z63| PDB=1z63 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z63 OCA], [https://pdbe.org/1z63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z63 RCSB], [https://www.ebi.ac.uk/pdbsum/1z63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z63 ProSAT]</span></td></tr>
 +
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z63_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z63 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
SWI2/SNF2 ATPases remodel chromatin or other DNA:protein complexes by a poorly understood mechanism that involves ATP-dependent DNA translocation and generation of superhelical torsion. Crystal structures of a dsDNA-translocating SWI2/SNF2 ATPase core from Sulfolobus solfataricus reveal two helical SWI2/SNF2 specific subdomains, fused to a DExx box helicase-related ATPase core. Fully base paired duplex DNA binds along a central cleft via both minor groove strands, indicating that SWI2/SNF2 ATPases travel along the dsDNA minor groove without strand separation. A structural switch, linking DNA binding and the active site DExx motif, may account for the stimulation of ATPase activity by dsDNA. Our results suggest that torque in remodeling processes is generated by an ATP-driven screw motion of DNA along the active site cleft. The structures also redefine SWI2/SNF2 functional motifs and uncover unexpected structural correlation of mutations in Cockayne and X-linked mental retardation syndromes.
-
'''Sulfolobus solfataricus SWI2/SNF2 ATPase core in complex with dsDNA'''
+
X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA.,Durr H, Korner C, Muller M, Hickmann V, Hopfner KP Cell. 2005 May 6;121(3):363-73. PMID:15882619<ref>PMID:15882619</ref>
-
 
+
-
 
+
-
==Overview==
+
-
SWI2/SNF2 ATPases remodel chromatin or other DNA:protein complexes by a poorly understood mechanism that involves ATP-dependent DNA translocation and generation of superhelical torsion. Crystal structures of a dsDNA-translocating SWI2/SNF2 ATPase core from Sulfolobus solfataricus reveal two helical SWI2/SNF2 specific subdomains, fused to a DExx box helicase-related ATPase core. Fully base paired duplex DNA binds along a central cleft via both minor groove strands, indicating that SWI2/SNF2 ATPases travel along the dsDNA minor groove without strand separation. A structural switch, linking DNA binding and the active site DExx motif, may account for the stimulation of ATPase activity by dsDNA. Our results suggest that torque in remodeling processes is generated by an ATP-driven screw motion of DNA along the active site cleft. The structures also redefine SWI2/SNF2 functional motifs and uncover unexpected structural correlation of mutations in Cockayne and X-linked mental retardation syndromes.
+
-
==About this Structure==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
1Z63 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z63 OCA].
+
</div>
 +
<div class="pdbe-citations 1z63" style="background-color:#fffaf0;"></div>
-
==Reference==
+
==See Also==
-
X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA., Durr H, Korner C, Muller M, Hickmann V, Hopfner KP, Cell. 2005 May 6;121(3):363-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15882619 15882619]
+
*[[Helicase 3D structures|Helicase 3D structures]]
-
[[Category: Single protein]]
+
== References ==
-
[[Category: Sulfolobus solfataricus]]
+
<references/>
-
[[Category: Duerr, H.]]
+
__TOC__
-
[[Category: Hickmann, V.]]
+
</StructureSection>
-
[[Category: Hopfner, K P.]]
+
[[Category: Large Structures]]
-
[[Category: Koerner, C.]]
+
[[Category: Saccharolobus solfataricus]]
-
[[Category: Mueller, M.]]
+
[[Category: Duerr H]]
-
[[Category: Protein-dna complex]]
+
[[Category: Hickmann V]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:13:08 2008''
+
[[Category: Hopfner KP]]
 +
[[Category: Koerner C]]
 +
[[Category: Mueller M]]

Current revision

Sulfolobus solfataricus SWI2/SNF2 ATPase core in complex with dsDNA

PDB ID 1z63

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z63"
Personal tools