1zih

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[[Image:1zih.gif|left|200px]]
 
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==GCAA RNA TETRALOOP, NMR, 10 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1zih", creates the "Structure Box" on the page.
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<StructureSection load='1zih' size='340' side='right'caption='[[1zih]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zih]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZIH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zih OCA], [https://pdbe.org/1zih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zih RCSB], [https://www.ebi.ac.uk/pdbsum/1zih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zih ProSAT]</span></td></tr>
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{{STRUCTURE_1zih| PDB=1zih | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''GCAA RNA TETRALOOP, NMR, 10 STRUCTURES'''
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== Publication Abstract from PubMed ==
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==Overview==
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RNA hairpin loops containing a GNRA consensus sequence are the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA-RNA tertiary interactions and as protein binding sites. Homo and heteronuclear NMR spectroscopy have been used to determine the structures of the most abundant members of the GNRA tetraloop family: the GAGA, GCAA and GAAA loops closed by a C-G base pair. Analysis of the structures of these three hairpin loops reveals a network of heterogeneous hydrogen bonds. The loops contain a G-A base pair, a G base-phosphate hydrogen bond and several 2' OH-base hydrogen bonds. These intramolecular interactions and the extensive base stacking in the loop help explain the high thermodynamic stability and give insight into the diverse biological roles of the GNRA RNA hairpins.
RNA hairpin loops containing a GNRA consensus sequence are the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA-RNA tertiary interactions and as protein binding sites. Homo and heteronuclear NMR spectroscopy have been used to determine the structures of the most abundant members of the GNRA tetraloop family: the GAGA, GCAA and GAAA loops closed by a C-G base pair. Analysis of the structures of these three hairpin loops reveals a network of heterogeneous hydrogen bonds. The loops contain a G-A base pair, a G base-phosphate hydrogen bond and several 2' OH-base hydrogen bonds. These intramolecular interactions and the extensive base stacking in the loop help explain the high thermodynamic stability and give insight into the diverse biological roles of the GNRA RNA hairpins.
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==About this Structure==
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A network of heterogeneous hydrogen bonds in GNRA tetraloops.,Jucker FM, Heus HA, Yip PF, Moors EH, Pardi A J Mol Biol. 1996 Dec 20;264(5):968-80. PMID:9000624<ref>PMID:9000624</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIH OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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A network of heterogeneous hydrogen bonds in GNRA tetraloops., Jucker FM, Heus HA, Yip PF, Moors EH, Pardi A, J Mol Biol. 1996 Dec 20;264(5):968-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9000624 9000624]
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</div>
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[[Category: Heus, H A.]]
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<div class="pdbe-citations 1zih" style="background-color:#fffaf0;"></div>
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[[Category: Jucker, F M.]]
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== References ==
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[[Category: Moors, E.]]
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<references/>
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[[Category: Pardi, A.]]
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__TOC__
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[[Category: Yip, P F.]]
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</StructureSection>
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[[Category: Gnra]]
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[[Category: Large Structures]]
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[[Category: Hairpin]]
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[[Category: Heus HA]]
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[[Category: Ribonucleic acid]]
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[[Category: Jucker FM]]
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[[Category: Rna]]
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[[Category: Moors E]]
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[[Category: Tetraloop]]
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[[Category: Pardi A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:40:00 2008''
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[[Category: Yip PF]]

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GCAA RNA TETRALOOP, NMR, 10 STRUCTURES

PDB ID 1zih

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