1ztn

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[[Image:1ztn.gif|left|200px]]
 
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==INACTIVATION GATE OF POTASSIUM CHANNEL RAW3, NMR, 8 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1ztn", creates the "Structure Box" on the page.
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<StructureSection load='1ztn' size='340' side='right'caption='[[1ztn]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ztn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZTN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ztn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ztn OCA], [https://pdbe.org/1ztn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ztn RCSB], [https://www.ebi.ac.uk/pdbsum/1ztn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ztn ProSAT]</span></td></tr>
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{{STRUCTURE_1ztn| PDB=1ztn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCNC4_HUMAN KCNC4_HUMAN] This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
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'''INACTIVATION GATE OF POTASSIUM CHANNEL RAW3, NMR, 8 STRUCTURES'''
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The electrical signalling properties of neurons originate largely from the gating properties of their ion channels. N-type inactivation of voltage-gated potassium (Kv) channels is the best-understood gating transition in ion channels, and occurs by a 'ball-and-chain' type mechanism. In this mechanism an N-terminal domain (inactivation gate), which is tethered to the cytoplasmic side of the channel protein by a protease-cleavable chain, binds to its receptor at the inner vestibule of the channel, thereby physically blocking the pore. Even when synthesized as a peptide, ball domains restore inactivation in Kv channels whose inactivation domains have been deleted. Using high-resolution nuclear magnetic resonance (NMR) spectroscopy, we analysed the three-dimensional structure of the ball peptides from two rapidly inactivating mammalian K. channels (Raw3 (Kv3.4) and RCK4 (Kv1.4)). The inactivation peptide of Raw3 (Raw3-IP) has a compact structure that exposes two phosphorylation sites and allows the formation of an intramolecular disulphide bridge between two spatially close cysteine residues. Raw3-IP exhibits a characteristic surface charge pattern with a positively charged, a hydrophobic, and a negatively charged region. The RCK4 inactivation peptide (RCK4-IP) shows a similar spatial distribution of charged and uncharged regions, but is more flexible and less ordered in its amino-terminal part.
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==About this Structure==
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1ZTN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTN OCA].
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==Reference==
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NMR structure of inactivation gates from mammalian voltage-dependent potassium channels., Antz C, Geyer M, Fakler B, Schott MK, Guy HR, Frank R, Ruppersberg JP, Kalbitzer HR, Nature. 1997 Jan 16;385(6613):272-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9000078 9000078]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Antz, C.]]
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[[Category: Antz C]]
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[[Category: Fakler, B.]]
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[[Category: Fakler B]]
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[[Category: Frank, R.]]
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[[Category: Frank R]]
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[[Category: Geyer, M.]]
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[[Category: Geyer M]]
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[[Category: Guy, H R.]]
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[[Category: Guy HR]]
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[[Category: Kalbitzer, H R.]]
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[[Category: Kalbitzer HR]]
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[[Category: Ruppersberg, J P.]]
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[[Category: Ruppersberg JP]]
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[[Category: Schott, M.]]
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[[Category: Schott M]]
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[[Category: Inactivation gate]]
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[[Category: Nmr]]
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[[Category: Potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:03:33 2008''
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Current revision

INACTIVATION GATE OF POTASSIUM CHANNEL RAW3, NMR, 8 STRUCTURES

PDB ID 1ztn

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