This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2d9w
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2d9w" size="450" color="white" frame="true" align="right" spinBox="true" caption="2d9w" /> '''Solution structure of the PH domain of Dock...) |
|||
| (13 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2d9w.gif|left|200px]]<br /> | ||
| - | <applet load="2d9w" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2d9w" /> | ||
| - | '''Solution structure of the PH domain of Docking protein 2 from human'''<br /> | ||
| - | == | + | ==Solution structure of the PH domain of Docking protein 2 from human== |
| - | + | <StructureSection load='2d9w' size='340' side='right'caption='[[2d9w]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2d9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9W FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9w OCA], [https://pdbe.org/2d9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9w RCSB], [https://www.ebi.ac.uk/pdbsum/2d9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9w ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9w TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DOK2_HUMAN DOK2_HUMAN] DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/2d9w_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d9w ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | [[Category: Li | + | [[Category: Li H]] |
| - | + | [[Category: Tomizawa T]] | |
| - | [[Category: Tomizawa | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution structure of the PH domain of Docking protein 2 from human
| |||||||||||
Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Li H | Tomizawa T | Yokoyama S
