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200d

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[[Image:200d.gif|left|200px]]
 
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==STABLE LOOP IN THE CRYSTAL STRUCTURE OF THE INTERCALATED FOUR-STRANDED CYTOSINE-RICH METAZOAN TELOMERE==
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The line below this paragraph, containing "STRUCTURE_200d", creates the "Structure Box" on the page.
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<StructureSection load='200d' size='340' side='right'caption='[[200d]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[200d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=200D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=200D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=200d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=200d OCA], [https://pdbe.org/200d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=200d RCSB], [https://www.ebi.ac.uk/pdbsum/200d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=200d ProSAT]</span></td></tr>
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{{STRUCTURE_200d| PDB=200d | SCENE= }}
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</table>
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__TOC__
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'''STABLE LOOP IN THE CRYSTAL STRUCTURE OF THE INTERCALATED FOUR-STRANDED CYTOSINE-RICH METAZOAN TELOMERE'''
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Berger I]]
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==Overview==
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[[Category: Kang C]]
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In most metazoans, the telomeric cytosine-rich strand repeating sequence is d(TAACCC). The crystal structure of this sequence was solved to 1.9-A resolution. Four strands associate via the cytosine-containing parts to form a four-stranded intercalated structure held together by C.C+ hydrogen bonds. The base-paired strands are parallel to each other, and the two duplexes are intercalated into each other in opposite orientations. One TAA end forms a highly stabilized loop with the 5' thymine Hoogsteen-base-paired to the third adenine. The 5' end of this loop is in close proximity to the 3' end of one of the other intercalated cytosine strands. Instead of being entirely in a DNA duplex, this structure suggests the possibility of an alternative conformation for the cytosine-rich telomere strands.
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[[Category: Lockshin C]]
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[[Category: Moyzis R]]
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==About this Structure==
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[[Category: Ratliff R]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=200D OCA].
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[[Category: Rich A]]
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==Reference==
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Stable loop in the crystal structure of the intercalated four-stranded cytosine-rich metazoan telomere., Kang C, Berger I, Lockshin C, Ratliff R, Moyzis R, Rich A, Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3874-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7731999 7731999]
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[[Category: Berger, I.]]
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[[Category: Kang, C.]]
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[[Category: Lockshin, C.]]
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[[Category: Moyzis, R.]]
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[[Category: Ratliff, R.]]
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[[Category: Rich, A.]]
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[[Category: Base intercalated]]
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[[Category: Loop]]
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[[Category: Quadruple helix]]
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[[Category: Tetraplex]]
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[[Category: U-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:17:32 2008''
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Current revision

STABLE LOOP IN THE CRYSTAL STRUCTURE OF THE INTERCALATED FOUR-STRANDED CYTOSINE-RICH METAZOAN TELOMERE

PDB ID 200d

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