284d

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[[Image:284d.gif|left|200px]]
 
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==THE BI-LOOP, A NEW GENERAL FOUR-STRANDED DNA MOTIF==
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The line below this paragraph, containing "STRUCTURE_284d", creates the "Structure Box" on the page.
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<StructureSection load='284d' size='340' side='right'caption='[[284d]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[284d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=284D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=284D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_284d| PDB=284d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=284d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=284d OCA], [https://pdbe.org/284d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=284d RCSB], [https://www.ebi.ac.uk/pdbsum/284d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=284d ProSAT]</span></td></tr>
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</table>
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'''THE BI-LOOP, A NEW GENERAL FOUR-STRANDED DNA MOTIF'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Alazzouzi E]]
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The crystal structure of the cyclic octanucleotide d&lt;pATTCATTC&gt; contains two independent molecules that form a novel quadruplex by means of intermolecular Watson-Crick A.T pairs and base stacking. A virtually identical quadruplex composed of G.C pairs was found by earlier x-ray analysis of the linear heptamer d(GCATGCT), when the DNA was looped in the crystal. The close correspondence between these two structures of markedly dissimilar oligonucleotides suggests that they are both examples of a previously unrecognized motif. Their nucleotide sequences have little in common except for two separated 5'-purine-pyrimidine dinucleotides forming the quadruplex, and by implication these so-called "bi-loops" could occur widely in natural DNA. Such structures provide a mechanism for noncovalent linking of polynucleotides in vivo. Their capacity to associate by base stacking, demonstrated in the crystal structure of d(GCATGCT), creates a compact molecular framework made up of four DNA chains within which strand exchange could take place.
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[[Category: Escaja N]]
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[[Category: Grandas A]]
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==About this Structure==
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[[Category: Kennard O]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=284D OCA].
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[[Category: Lubini P]]
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[[Category: Pedroso E]]
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==Reference==
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[[Category: Powell HR]]
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The bi-loop, a new general four-stranded DNA motif., Salisbury SA, Wilson SE, Powell HR, Kennard O, Lubini P, Sheldrick GM, Escaja N, Alazzouzi E, Grandas A, Pedroso E, Proc Natl Acad Sci U S A. 1997 May 27;94(11):5515-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9159103 9159103]
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[[Category: Salisbury SA]]
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[[Category: Alazzouzi, E.]]
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[[Category: Sheldrick GM]]
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[[Category: Escaja, N.]]
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[[Category: Wilson SE]]
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[[Category: Grandas, A.]]
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[[Category: Kennard, O.]]
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[[Category: Lubini, P.]]
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[[Category: Pedroso, E.]]
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[[Category: Powell, H R.]]
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[[Category: Salisbury, S A.]]
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[[Category: Sheldrick, G M.]]
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[[Category: Wilson, S E.]]
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[[Category: Bi-loop]]
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[[Category: Cyclic b-dna]]
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[[Category: Quadruple helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:25:21 2008''
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Current revision

THE BI-LOOP, A NEW GENERAL FOUR-STRANDED DNA MOTIF

PDB ID 284d

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