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2dgv
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2dgv" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dgv" /> '''Solution structure of the RNA binding domai...) |
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| - | [[Image:2dgv.gif|left|200px]]<br /> | ||
| - | <applet load="2dgv" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2dgv" /> | ||
| - | '''Solution structure of the RNA binding domain in Heterogeneous nuclear ribonucleoprotein M'''<br /> | ||
| - | == | + | ==Solution structure of the RNA binding domain in Heterogeneous nuclear ribonucleoprotein M== |
| - | + | <StructureSection load='2dgv' size='340' side='right'caption='[[2dgv]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[2dgv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DGV FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dgv OCA], [https://pdbe.org/2dgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dgv RCSB], [https://www.ebi.ac.uk/pdbsum/2dgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dgv ProSAT], [https://www.topsan.org/Proteins/RSGI/2dgv TOPSAN]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | [ | + | [https://www.uniprot.org/uniprot/HNRPM_HUMAN HNRPM_HUMAN] Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | [ | + | Check<jmol> |
| - | [ | + | <jmolCheckbox> |
| - | [[ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/2dgv_consurf.spt"</scriptWhenChecked> |
| - | [ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dgv ConSurf]. | |
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Abe C]] | ||
| + | [[Category: Inoue M]] | ||
| + | [[Category: Kigawa T]] | ||
| + | [[Category: Muto Y]] | ||
| + | [[Category: Shirouzu M]] | ||
| + | [[Category: Terada T]] | ||
| + | [[Category: Yokoyama S]] | ||
Current revision
Solution structure of the RNA binding domain in Heterogeneous nuclear ribonucleoprotein M
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Categories: Homo sapiens | Large Structures | Abe C | Inoue M | Kigawa T | Muto Y | Shirouzu M | Terada T | Yokoyama S
