2dl6

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(New page: 200px<br /> <applet load="2dl6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dl6" /> '''Solution structure of the first BRK domain ...)
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[[Image:2dl6.gif|left|200px]]<br />
 
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<applet load="2dl6" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2dl6" />
 
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'''Solution structure of the first BRK domain from human chromodomain-helicase-DNA-binding protein 8'''<br />
 
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==About this Structure==
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==Solution structure of the first BRK domain from human chromodomain-helicase-DNA-binding protein 8==
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2DL6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DL6 OCA].
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<StructureSection load='2dl6' size='340' side='right'caption='[[2dl6]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2dl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DL6 FirstGlance]. <br>
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[[Category: Hayashi, F.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Nagashima, T.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dl6 OCA], [https://pdbe.org/2dl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dl6 RCSB], [https://www.ebi.ac.uk/pdbsum/2dl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dl6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dl6 TOPSAN]</span></td></tr>
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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</table>
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[[Category: Suetake, T.]]
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== Function ==
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[[Category: Yokoyama, S.]]
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[https://www.uniprot.org/uniprot/CHD8_HUMAN CHD8_HUMAN] DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.<ref>PMID:17938208</ref> <ref>PMID:18378692</ref>
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[[Category: brk]]
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== Evolutionary Conservation ==
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[[Category: chd8]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: national project on protein structural and functional analyses]]
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Check<jmol>
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[[Category: nppsfa]]
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<jmolCheckbox>
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[[Category: riken structural genomics/proteomics initiative]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/2dl6_consurf.spt"</scriptWhenChecked>
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[[Category: rsgi]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: structural genomics]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dl6 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:35:34 2007''
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==See Also==
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*[[Chromodomain-helicase-DNA-binding protein 3D structures|Chromodomain-helicase-DNA-binding protein 3D structures]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hayashi F]]
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[[Category: Nagashima T]]
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[[Category: Suetake T]]
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[[Category: Yokoyama S]]

Current revision

Solution structure of the first BRK domain from human chromodomain-helicase-DNA-binding protein 8

PDB ID 2dl6

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