2a91

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[[Image:2a91.gif|left|200px]]
 
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==Crystal structure of ErbB2 domains 1-3==
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The line below this paragraph, containing "STRUCTURE_2a91", creates the "Structure Box" on the page.
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<StructureSection load='2a91' size='340' side='right'caption='[[2a91]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A91 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_2a91| PDB=2a91 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a91 OCA], [https://pdbe.org/2a91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a91 RCSB], [https://www.ebi.ac.uk/pdbsum/2a91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a91 ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of ErbB2 domains 1-3'''
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==Overview==
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/2a91_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a91 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
ErbB2 does not bind ligand, yet appears to be the major signaling partner for other ErbB receptors by forming heteromeric complexes with ErbB1, ErbB3, or ErbB4. The crystal structure of residues 1-509 of ErbB2 at 2.5 A resolution reveals an activated conformation similar to that of the EGFR when complexed with ligand and very different from that seen in the unactivated forms of ErbB3 or EGFR. The structure explains the inability of ErbB2 to bind known ligands and suggests why ErbB2 fails to form homodimers. Together, the data suggest a model in which ErbB2 is already in the activated conformation and ready to interact with other ligand-activated ErbB receptors.
ErbB2 does not bind ligand, yet appears to be the major signaling partner for other ErbB receptors by forming heteromeric complexes with ErbB1, ErbB3, or ErbB4. The crystal structure of residues 1-509 of ErbB2 at 2.5 A resolution reveals an activated conformation similar to that of the EGFR when complexed with ligand and very different from that seen in the unactivated forms of ErbB3 or EGFR. The structure explains the inability of ErbB2 to bind known ligands and suggests why ErbB2 fails to form homodimers. Together, the data suggest a model in which ErbB2 is already in the activated conformation and ready to interact with other ligand-activated ErbB receptors.
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==About this Structure==
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The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors.,Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Kofler M, Jorissen RN, Nice EC, Burgess AW, Ward CW Mol Cell. 2003 Feb;11(2):495-505. PMID:12620236<ref>PMID:12620236</ref>
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2A91 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A91 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors., Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Kofler M, Jorissen RN, Nice EC, Burgess AW, Ward CW, Mol Cell. 2003 Feb;11(2):495-505. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12620236 12620236]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 2a91" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Transferase]]
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<references/>
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[[Category: Adams, T E.]]
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__TOC__
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[[Category: Burgess, A W.]]
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</StructureSection>
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[[Category: Elleman, T C.]]
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[[Category: Large Structures]]
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[[Category: Garrett, T P.J.]]
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[[Category: Adams TE]]
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[[Category: Jorissen, R N.]]
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[[Category: Burgess AW]]
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[[Category: Kofler, M.]]
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[[Category: Elleman TC]]
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[[Category: Lou, M.]]
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[[Category: Garrett TPJ]]
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[[Category: Lovrecz, G O.]]
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[[Category: Jorissen RN]]
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[[Category: McKern, N M.]]
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[[Category: Kofler M]]
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[[Category: Nice, E C.]]
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[[Category: Lou M]]
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[[Category: Cell-surface receptor]]
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[[Category: Lovrecz GO]]
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[[Category: Tyrosine kinase receptor]]
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[[Category: McKern NM]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:45:46 2008''
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[[Category: Nice EC]]

Current revision

Crystal structure of ErbB2 domains 1-3

PDB ID 2a91

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