2abi

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[[Image:2abi.gif|left|200px]]
 
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==Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone==
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The line below this paragraph, containing "STRUCTURE_2abi", creates the "Structure Box" on the page.
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<StructureSection load='2abi' size='340' side='right'caption='[[2abi]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2abi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ABI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CA:DESOXYCORTICOSTERONE'>1CA</scene></td></tr>
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{{STRUCTURE_2abi| PDB=2abi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2abi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abi OCA], [https://pdbe.org/2abi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2abi RCSB], [https://www.ebi.ac.uk/pdbsum/2abi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2abi ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MCR_HUMAN MCR_HUMAN] Defects in NR3C2 are a cause of pseudohypoaldosteronism 1, autosomal dominant (PHA1A) [MIM:[https://omim.org/entry/177735 177735]. A salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. PHA1A is a mild form characterized by target organ defects confined to kidney. Patients may present with neonatal renal salt wasting with hyperkalaemic acidosis despite high aldosterone levels. These patients improve with age and usually become asymptomatic without treatment.<ref>PMID:9662404</ref> <ref>PMID:11134129</ref> <ref>PMID:12788847</ref> <ref>PMID:16954160</ref> <ref>PMID:16972228</ref> Defects in NR3C2 are a cause of early-onset hypertension with severe exacerbation in pregnancy (EOHSEP) [MIM:[https://omim.org/entry/605115 605115]. Inheritance is autosomal dominant. The disease is characterized by the onset of severe hypertension before the age of 20, and by suppression of aldosterone secretion.<ref>PMID:9662404</ref> <ref>PMID:15967794</ref> <ref>PMID:15908963</ref> <ref>PMID:10884226</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MCR_HUMAN MCR_HUMAN] Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.<ref>PMID:3037703</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/2abi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2abi ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone'''
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==See Also==
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*[[Mineralocorticoid receptor|Mineralocorticoid receptor]]
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== References ==
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==About this Structure==
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<references/>
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2ABI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABI OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Fagart, J.]]
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[[Category: Fagart J]]
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[[Category: Huyet, J.]]
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[[Category: Huyet J]]
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[[Category: Mayer, C.]]
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[[Category: Mayer C]]
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[[Category: Pinon, G M.]]
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[[Category: Pinon G-M]]
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[[Category: Rafestin-Oblin, M E.]]
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[[Category: Rafestin-Oblin M-E]]
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[[Category: Rochel, M.]]
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[[Category: Rochel M]]
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[[Category: Activating mutation]]
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[[Category: Hypertension]]
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[[Category: Mineralocorticoid receptor]]
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[[Category: Nuclear recept]]
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[[Category: Steroid recepto]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:51:01 2008''
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Current revision

Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone

PDB ID 2abi

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