2acg

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[[Image:2acg.gif|left|200px]]
 
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==ACANTHAMOEBA CASTELLANII PROFILIN II==
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The line below this paragraph, containing "STRUCTURE_2acg", creates the "Structure Box" on the page.
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<StructureSection load='2acg' size='340' side='right'caption='[[2acg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2acg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ACG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2acg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2acg OCA], [https://pdbe.org/2acg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2acg RCSB], [https://www.ebi.ac.uk/pdbsum/2acg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2acg ProSAT]</span></td></tr>
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{{STRUCTURE_2acg| PDB=2acg | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PROF2_ACACA PROF2_ACACA] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/2acg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2acg ConSurf].
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<div style="clear:both"></div>
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'''ACANTHAMOEBA CASTELLANII PROFILIN II'''
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==See Also==
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*[[Profilin 3D Structures|Profilin 3D Structures]]
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__TOC__
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==Overview==
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</StructureSection>
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We determined the structures of Acanthamoeba profilin I and profilin II by x-ray crystallography at resolutions of 2.0 and 2.8 A, respectively. The polypeptide folds and the actin-binding surfaces of the amoeba profilins are very similar to those of bovine and human profilins. The electrostatic potential surfaces of the two Acanthamoeba isoforms differ. Two areas of high positive potential on the surface of profilin II are candidate binding sites for phosphatidylinositol phosphates. The proximity of these sites to the actin binding site provides an explanation for the competition between actin and lipids for binding profilin.
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==About this Structure==
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2ACG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACG OCA].
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==Reference==
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X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates., Fedorov AA, Magnus KA, Graupe MH, Lattman EE, Pollard TD, Almo SC, Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8636-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8078936 8078936]
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[[Category: Acanthamoeba castellanii]]
[[Category: Acanthamoeba castellanii]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Fedorov, A A.]]
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[[Category: Fedorov AA]]
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[[Category: Graupe, M H.]]
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[[Category: Graupe MH]]
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[[Category: Lattman, E E.]]
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[[Category: Lattman EE]]
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[[Category: Magnus, K A.]]
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[[Category: Magnus KA]]
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[[Category: Pollard, T D.]]
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[[Category: Pollard TD]]
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[[Category: Actin-binding protein]]
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[[Category: Profilin]]
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[[Category: Protein binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:52:31 2008''
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Current revision

ACANTHAMOEBA CASTELLANII PROFILIN II

PDB ID 2acg

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