2afr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:41, 13 March 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2afr.gif|left|200px]]
 
-
<!--
+
==The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis==
-
The line below this paragraph, containing "STRUCTURE_2afr", creates the "Structure Box" on the page.
+
<StructureSection load='2afr' size='340' side='right'caption='[[2afr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2afr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AFR FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2afr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2afr OCA], [https://pdbe.org/2afr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2afr RCSB], [https://www.ebi.ac.uk/pdbsum/2afr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2afr ProSAT]</span></td></tr>
-
{{STRUCTURE_2afr| PDB=2afr | SCENE= }}
+
</table>
-
 
+
== Function ==
-
'''The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis'''
+
[https://www.uniprot.org/uniprot/CBIC_LEPIN CBIC_LEPIN] Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate.
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==Overview==
+
Check<jmol>
-
The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement reaction of the cobalamin biosynthesis pathway. The protein has been cloned and overexpressed as a His-tagged recombinant protein in Escherichia coli. The crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12.
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/2afr_consurf.spt"</scriptWhenChecked>
-
==About this Structure==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
2AFR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFR OCA].
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==Reference==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2afr ConSurf].
-
The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis., Xue Y, Wei Z, Li X, Gong W, J Struct Biol. 2006 Mar;153(3):307-11. Epub 2005 Dec 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16427313 16427313]
+
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Leptospira interrogans]]
[[Category: Leptospira interrogans]]
-
[[Category: Precorrin-8X methylmutase]]
+
[[Category: Li X]]
-
[[Category: Single protein]]
+
[[Category: Wei Z]]
-
[[Category: Li, X.]]
+
[[Category: Xue Y]]
-
[[Category: Wei, Z.]]
+
-
[[Category: Xue, Y.]]
+
-
[[Category: Isomerase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:59:54 2008''
+

Current revision

The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis

PDB ID 2afr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2afr"
Personal tools