2agh

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[[Image:2agh.gif|left|200px]]
 
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==Structural basis for cooperative transcription factor binding to the CBP coactivator==
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The line below this paragraph, containing "STRUCTURE_2agh", creates the "Structure Box" on the page.
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<StructureSection load='2agh' size='340' side='right'caption='[[2agh]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2agh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AGH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2agh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2agh OCA], [https://pdbe.org/2agh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2agh RCSB], [https://www.ebi.ac.uk/pdbsum/2agh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2agh ProSAT]</span></td></tr>
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{{STRUCTURE_2agh| PDB=2agh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/2agh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2agh ConSurf].
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<div style="clear:both"></div>
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'''Structural basis for cooperative transcription factor binding to the CBP coactivator'''
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==See Also==
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*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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==Overview==
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__TOC__
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Regulation of transcription requires interactions between transcriptional activators and transcriptional co-activator CREB binding protein (CBP). The KIX domain of CBP can bind simultaneously to two different proteins, providing an additional mechanism for transcriptional regulation. Here we describe the solution structure of the ternary complex formed by cooperative binding of activation domains from the c-Myb and mixed lineage leukemia (MLL) transcription factors to the KIX domain. The MLL and c-Myb domains form helices that bind to two distinct hydrophobic grooves on opposite faces of KIX. Compared to the binary KIX:c-Myb complex, significant changes are observed in the structure of KIX at the MLL binding interface in the ternary complex. Two regions of KIX that are disordered in the binary complex become structured in the ternary complex: a flexible loop forms intimate contacts with bound MLL, and the C-terminal helix is extended and stabilized by MLL binding. This structural change results in the formation of additional electrostatic/polar interactions between KIX and the bound c-Myb, providing a structural basis for the cooperativity observed for the ternary complex.
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</StructureSection>
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==About this Structure==
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2AGH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AGH OCA].
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==Reference==
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Structural basis for cooperative transcription factor binding to the CBP coactivator., De Guzman RN, Goto NK, Dyson HJ, Wright PE, J Mol Biol. 2006 Feb 3;355(5):1005-13. Epub 2005 Oct 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16253272 16253272]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: De Guzman RN]]
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[[Category: Dyson, H J.]]
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[[Category: Dyson HJ]]
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[[Category: Goto, N K.]]
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[[Category: Goto NK]]
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[[Category: Guzman, R N.De.]]
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[[Category: Wright PE]]
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[[Category: Wright, P E.]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:01:13 2008''
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Current revision

Structural basis for cooperative transcription factor binding to the CBP coactivator

PDB ID 2agh

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