2agn

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[[Image:2agn.gif|left|200px]]
 
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==Fitting of hepatitis C virus internal ribosome entry site domains into the 15 A Cryo-EM map of a HCV IRES-80S ribosome (H. sapiens) complex==
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The line below this paragraph, containing "STRUCTURE_2agn", creates the "Structure Box" on the page.
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<SX load='2agn' size='340' side='right' viewer='molstar' caption='[[2agn]], [[Resolution|resolution]] 15.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2agn]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AGN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2agn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2agn OCA], [https://pdbe.org/2agn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2agn RCSB], [https://www.ebi.ac.uk/pdbsum/2agn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2agn ProSAT]</span></td></tr>
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{{STRUCTURE_2agn| PDB=2agn | SCENE= }}
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</table>
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__TOC__
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'''Fitting of hepatitis C virus internal ribosome entry site domains into the 15 A Cryo-EM map of a HCV IRES-80S ribosome (H. sapiens) complex'''
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</SX>
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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==Overview==
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[[Category: Boehringer D]]
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Initiation of translation of the hepatitis C virus (HCV) polyprotein is driven by an internal ribosome entry site (IRES) RNA that bypasses much of the eukaryotic translation initiation machinery. Here, single-particle electron cryomicroscopy has been used to study the mechanism of HCV IRES-mediated initiation. A HeLa in vitro translation system was used to assemble human IRES-80S ribosome complexes under near physiological conditions; these were stalled before elongation. Domain 2 of the HCV IRES is bound to the tRNA exit site, touching the L1 stalk of the 60S subunit, suggesting a mechanism for the removal of the HCV IRES in the progression to elongation. Domain 3 of the HCV IRES positions the initiation codon in the ribosomal mRNA binding cleft by binding helix 28 at the head of the 40S subunit. The comparison with the previously published binary 40S-HCV IRES complex reveals structural rearrangements in the two pseudoknot structures of the HCV IRES in translation initiation.
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[[Category: Lewis JD]]
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[[Category: Ostareck-Lederer A]]
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==About this Structure==
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[[Category: Stark H]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AGN OCA].
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[[Category: Thermann R]]
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==Reference==
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Structure of the hepatitis C Virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES., Boehringer D, Thermann R, Ostareck-Lederer A, Lewis JD, Stark H, Structure. 2005 Nov;13(11):1695-706. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16271893 16271893]
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[[Category: Boehringer, D.]]
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[[Category: Lewis, J D.]]
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[[Category: Ostareck-Lederer, A.]]
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[[Category: Stark, H.]]
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[[Category: Thermann, R.]]
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[[Category: Hcv]]
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[[Category: Ire]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:01:34 2008''
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Current revision

Fitting of hepatitis C virus internal ribosome entry site domains into the 15 A Cryo-EM map of a HCV IRES-80S ribosome (H. sapiens) complex

2agn, resolution 15.00Å

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OCA

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