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2e1o

From Proteopedia

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(New page: 200px<br /> <applet load="2e1o" size="450" color="white" frame="true" align="right" spinBox="true" caption="2e1o" /> '''Solution structure of RSGI RUH-028, a homeo...)
Current revision (18:46, 29 May 2024) (edit) (undo)
 
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[[Image:2e1o.gif|left|200px]]<br />
 
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<applet load="2e1o" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2e1o" />
 
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'''Solution structure of RSGI RUH-028, a homeobox domain from human cDNA'''<br />
 
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==Disease==
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==Solution structure of RSGI RUH-028, a homeobox domain from human cDNA==
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Known diseases associated with this structure: GM2-gangliosidosis, several forms OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606869 606869]], Hex A pseudodeficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606869 606869]], Tay-Sachs disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606869 606869]]
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<StructureSection load='2e1o' size='340' side='right'caption='[[2e1o]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2e1o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wqi 1wqi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E1O FirstGlance]. <br>
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2E1O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure superseeds the now removed PDB entry 1WQI. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2E1O OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e1o OCA], [https://pdbe.org/2e1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e1o RCSB], [https://www.ebi.ac.uk/pdbsum/2e1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e1o ProSAT], [https://www.topsan.org/Proteins/RSGI/2e1o TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HHEX_HUMAN HHEX_HUMAN] Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/2e1o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e1o ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Abe, T.]]
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[[Category: Abe T]]
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[[Category: Hirota, H.]]
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[[Category: Hirota H]]
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[[Category: Kawaii, S.]]
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[[Category: Kawaii S]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: Nakamura, A.]]
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[[Category: Nakamura A]]
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[[Category: Nameki, N.]]
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[[Category: Nameki N]]
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[[Category: Ohnishi, S.]]
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[[Category: Ohnishi S]]
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: dna binding protein]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:44:45 2007''
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Current revision

Solution structure of RSGI RUH-028, a homeobox domain from human cDNA

PDB ID 2e1o

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