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2e5z

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(New page: 200px<br /> <applet load="2e5z" size="450" color="white" frame="true" align="right" spinBox="true" caption="2e5z" /> '''Solution structure of the surp2 domain in s...)
Current revision (18:47, 29 May 2024) (edit) (undo)
 
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[[Image:2e5z.gif|left|200px]]<br />
 
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<applet load="2e5z" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2e5z" />
 
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'''Solution structure of the surp2 domain in splicing factor, arginine/serine-rich 8'''<br />
 
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==About this Structure==
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==Solution structure of the surp2 domain in splicing factor, arginine/serine-rich 8==
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2E5Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2E5Z OCA].
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<StructureSection load='2e5z' size='340' side='right'caption='[[2e5z]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2e5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5z OCA], [https://pdbe.org/2e5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5z RCSB], [https://www.ebi.ac.uk/pdbsum/2e5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5z ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5z TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SFSWA_HUMAN SFSWA_HUMAN] Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:8940107</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5z ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: He, F.]]
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[[Category: He F]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y.]]
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[[Category: Muto Y]]
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nmr]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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[[Category: surp domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:46:07 2007''
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Current revision

Solution structure of the surp2 domain in splicing factor, arginine/serine-rich 8

PDB ID 2e5z

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