2e7h

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(New page: 200px<br /> <applet load="2e7h" size="450" color="white" frame="true" align="right" spinBox="true" caption="2e7h" /> '''Solution structure of the second fn3 domain...)
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[[Image:2e7h.gif|left|200px]]<br />
 
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<applet load="2e7h" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2e7h" />
 
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'''Solution structure of the second fn3 domain from human Ephrin type-B receptor 4'''<br />
 
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==About this Structure==
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==Solution structure of the second fn3 domain from human Ephrin type-B receptor 4==
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2E7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2E7H OCA].
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<StructureSection load='2e7h' size='340' side='right'caption='[[2e7h]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Receptor protein-tyrosine kinase]]
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<table><tr><td colspan='2'>[[2e7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E7H FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Hayashi, F.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7h OCA], [https://pdbe.org/2e7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e7h RCSB], [https://www.ebi.ac.uk/pdbsum/2e7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7h ProSAT], [https://www.topsan.org/Proteins/RSGI/2e7h TOPSAN]</span></td></tr>
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[[Category: Qin, X.R.]]
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</table>
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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== Function ==
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[[Category: Yokoyama, S.]]
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[https://www.uniprot.org/uniprot/EPHB4_HUMAN EPHB4_HUMAN] Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.<ref>PMID:12734395</ref> <ref>PMID:16424904</ref>
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[[Category: ephrin type-b receptor 4 precursor]]
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== Evolutionary Conservation ==
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[[Category: fn3 domain]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: national project on protein structural and functional analyses]]
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Check<jmol>
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[[Category: nppsfa]]
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<jmolCheckbox>
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[[Category: riken structural genomics/proteomics initiative]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/2e7h_consurf.spt"</scriptWhenChecked>
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[[Category: rsgi]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: structural genomics]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: tyrosine-protein kinase receptor htk]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e7h ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:46:46 2007''
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==See Also==
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*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hayashi F]]
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[[Category: Qin XR]]
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[[Category: Yokoyama S]]

Current revision

Solution structure of the second fn3 domain from human Ephrin type-B receptor 4

PDB ID 2e7h

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