2avf

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[[Image:2avf.gif|left|200px]]
 
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==Crystal Structure of C-terminal Desundecapeptide Nitrite Reductase from Achromobacter cycloclastes==
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The line below this paragraph, containing "STRUCTURE_2avf", creates the "Structure Box" on the page.
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<StructureSection load='2avf' size='340' side='right'caption='[[2avf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2avf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Achromobacter_cycloclastes Achromobacter cycloclastes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AVF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
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{{STRUCTURE_2avf| PDB=2avf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2avf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2avf OCA], [https://pdbe.org/2avf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2avf RCSB], [https://www.ebi.ac.uk/pdbsum/2avf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2avf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NIR_ACHCY NIR_ACHCY]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/av/2avf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2avf ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of C-terminal Desundecapeptide Nitrite Reductase from Achromobacter cycloclastes'''
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==See Also==
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*[[Nitrite reductase 3D structures|Nitrite reductase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Monoclinic crystal structure of C-terminal desundecapeptide nitrite reductase (NiRc-11) from Achromobacter cycloclastes was determined at 2.6A. NiRc-11 exists as a loose trimer in the crystal. Deletion of 11 residues eliminates all intersubunit hydrogen bonds mediated by the C-terminal tail. The rigid irregular coil 105-112, which constitutes part of the sidewall of the active site pocket, undergoes conformational changes and becomes highly flexible in NiRc-11. Correspondingly, the linker segments between the two copper sites 95-100 and 135-136 are partly relaxed in conformation, which leads to disrupted active site microenvironments responsible for the activity loss and spectral change of NiRc-11. Comparison with the native structure revealed a bulky residue Met331 fastened by hydrogen bonding, which may play a direct role in keeping the right copper site geometry by protruding its side chain against the irregular coil 105-112. Sequence alignment showed that the bulky residue is conserved at position 331, indicating an equal importance of C-terminal segment in other copper-containing nitrite reductases.
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==About this Structure==
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2AVF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Achromobacter_cycloclastes Achromobacter cycloclastes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AVF OCA].
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==Reference==
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Crystal structure of C-terminal desundecapeptide nitrite reductase from Achromobacter cycloclastes., Li HT, Chang T, Chang WC, Chen CJ, Liu MY, Gui LL, Zhang JP, An XM, Chang WR, Biochem Biophys Res Commun. 2005 Dec 30;338(4):1935-42. Epub 2005 Nov 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16293231 16293231]
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[[Category: Achromobacter cycloclastes]]
[[Category: Achromobacter cycloclastes]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: An, X M.]]
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[[Category: An XM]]
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[[Category: Chang, T.]]
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[[Category: Chang T]]
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[[Category: Chang, W C.]]
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[[Category: Chang WC]]
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[[Category: Chang, W R.]]
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[[Category: Chang WR]]
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[[Category: Chen, C J.]]
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[[Category: Chen CJ]]
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[[Category: Gui, L L.]]
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[[Category: Gui LL]]
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[[Category: Li, H T.]]
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[[Category: Li HT]]
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[[Category: Liu, M Y.]]
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[[Category: Liu MY]]
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[[Category: Zhang, J P.]]
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[[Category: Zhang JP]]
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[[Category: Beta barrel trimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:31:10 2008''
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Current revision

Crystal Structure of C-terminal Desundecapeptide Nitrite Reductase from Achromobacter cycloclastes

PDB ID 2avf

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