|
|
| (9 intermediate revisions not shown.) |
| Line 1: |
Line 1: |
| - | [[Image:2b2r.gif|left|200px]] | + | #REDIRECT [[5sw6]] This PDB entry is obsolete and replaced by 5sw6 |
| - | | + | |
| - | <!--
| + | |
| - | The line below this paragraph, containing "STRUCTURE_2b2r", creates the "Structure Box" on the page.
| + | |
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet)
| + | |
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| + | |
| - | or leave the SCENE parameter empty for the default display.
| + | |
| - | -->
| + | |
| - | {{STRUCTURE_2b2r| PDB=2b2r | SCENE= }}
| + | |
| - | | + | |
| - | '''Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH5.6'''
| + | |
| - | | + | |
| - | | + | |
| - | ==Overview==
| + | |
| - | The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.
| + | |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | 2B2R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2R OCA].
| + | |
| - | | + | |
| - | ==Reference==
| + | |
| - | A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16211084 16211084]
| + | |
| - | [[Category: Burkholderia pseudomallei]]
| + | |
| - | [[Category: Catalase]]
| + | |
| - | [[Category: Single protein]]
| + | |
| - | [[Category: Carpena, X.]]
| + | |
| - | [[Category: Deemagarn, T.]]
| + | |
| - | [[Category: Fita, I.]]
| + | |
| - | [[Category: Ivancich, A.]]
| + | |
| - | [[Category: Loewen, P C.]]
| + | |
| - | [[Category: Singh, R.]]
| + | |
| - | [[Category: Switala, J.]]
| + | |
| - | [[Category: Wiseman, B.]]
| + | |
| - | [[Category: Catalase-peroxidase]]
| + | |
| - | [[Category: Compound i]]
| + | |
| - | [[Category: Katg]]
| + | |
| - | [[Category: Oxoferryl species]]
| + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:46:35 2008''
| + | |
