2b3s

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[[Image:2b3s.jpg|left|200px]]
 
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==structure of the DSBA mutant (P31G-C33A)==
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The line below this paragraph, containing "STRUCTURE_2b3s", creates the "Structure Box" on the page.
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<StructureSection load='2b3s' size='340' side='right'caption='[[2b3s]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2b3s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B3S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3s OCA], [https://pdbe.org/2b3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b3s RCSB], [https://www.ebi.ac.uk/pdbsum/2b3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3s ProSAT]</span></td></tr>
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{{STRUCTURE_2b3s| PDB=2b3s | SCENE= }}
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</table>
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== Function ==
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'''structure of the DSBA mutant (P31G-C33A)'''
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[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2B3S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3S OCA].
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<jmolCheckbox>
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[[Category: Escherichia coli]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b3s_consurf.spt"</scriptWhenChecked>
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[[Category: Single protein]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: Royant, A.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Serre, L.]]
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</jmolCheckbox>
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[[Category: Vives, C.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b3s ConSurf].
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[[Category: Disulfide]]
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<div style="clear:both"></div>
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[[Category: Thiol-oxydase]]
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== References ==
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[[Category: Thioredoxin]]
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:49:05 2008''
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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[[Category: Large Structures]]
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[[Category: Royant A]]
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[[Category: Serre L]]
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[[Category: Vives C]]

Current revision

structure of the DSBA mutant (P31G-C33A)

PDB ID 2b3s

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