2eq4

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(New page: 200px<br /> <applet load="2eq4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2eq4" /> '''Solution structure of the 11th C2H2 type zi...)
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[[Image:2eq4.gif|left|200px]]<br />
 
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<applet load="2eq4" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2eq4" />
 
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'''Solution structure of the 11th C2H2 type zinc finger domain of Zinc finger protein 224'''<br />
 
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==About this Structure==
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==Solution structure of the 11th C2H2 type zinc finger domain of Zinc finger protein 224==
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2EQ4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2EQ4 OCA].
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<StructureSection load='2eq4' size='340' side='right'caption='[[2eq4]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2eq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EQ4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eq4 OCA], [https://pdbe.org/2eq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eq4 RCSB], [https://www.ebi.ac.uk/pdbsum/2eq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eq4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eq4 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eq/2eq4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eq4 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Masuda, K.]]
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[[Category: Masuda K]]
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[[Category: Muto, Y.]]
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[[Category: Muto Y]]
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Suzuki S]]
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[[Category: Suzuki, S.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: ZN]]
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[[Category: c2h2]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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[[Category: transcription]]
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[[Category: zinc finger domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:54:06 2007''
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Current revision

Solution structure of the 11th C2H2 type zinc finger domain of Zinc finger protein 224

PDB ID 2eq4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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