2bbz

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[[Image:2bbz.gif|left|200px]]
 
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==Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition==
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The line below this paragraph, containing "STRUCTURE_2bbz", creates the "Structure Box" on the page.
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<StructureSection load='2bbz' size='340' side='right'caption='[[2bbz]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bbz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Molluscum_contagiosum_virus_subtype_1 Molluscum contagiosum virus subtype 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbz OCA], [https://pdbe.org/2bbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbz RCSB], [https://www.ebi.ac.uk/pdbsum/2bbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbz ProSAT]</span></td></tr>
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{{STRUCTURE_2bbz| PDB=2bbz | SCENE= }}
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</table>
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== Function ==
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'''Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition'''
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[https://www.uniprot.org/uniprot/CFLA_MCV1 CFLA_MCV1] Inhibits TNFRSF1A, TNFRSF6 and TNFRSF12 induced apoptosis. May interfere with caspase-8 recruitment and activation at the death-inducing signaling complex (DISC). May lead to higher virus production and contribute to virus persistence and oncogenicity.<ref>PMID:9087414</ref> <ref>PMID:9037025</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The death-inducing signaling complex (DISC) comprising Fas, Fas-associated death domain (FADD), and caspase-8/10 is assembled via homotypic associations between death domains (DDs) of Fas and FADD and between death effector domains (DEDs) of FADD and caspase-8/10. Caspase-8/10 and FLICE/caspase-8 inhibitory proteins (FLIPs) that inhibit caspase activation at the DISC level contain tandem DEDs. Here, we report the crystal structure of a viral FLIP, MC159, at 1.2 Angstroms resolution. It reveals a noncanonical fold of DED1, a dumbbell-shaped structure with rigidly associated DEDs and a different mode of interaction in the DD superfamily. Whereas the conserved hydrophobic patch of DED1 interacts with DED2, the corresponding region of DED2 mediates caspase-8 recruitment and contributes to DISC assembly. In contrast, MC159 cooperatively assembles with Fas and FADD via an extensive surface that encompasses the conserved charge triad. This interaction apparently competes with FADD self-association and disrupts higher-order oligomerization required for caspase activation in the DISC.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbz_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2BBZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Molluscum_contagiosum_virus_subtype_1 Molluscum contagiosum virus subtype 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBZ OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bbz ConSurf].
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Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition., Yang JK, Wang L, Zheng L, Wan F, Ahmed M, Lenardo MJ, Wu H, Mol Cell. 2005 Dec 22;20(6):939-49. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16364918 16364918]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Molluscum contagiosum virus subtype 1]]
[[Category: Molluscum contagiosum virus subtype 1]]
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[[Category: Single protein]]
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[[Category: Ahmed M]]
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[[Category: Ahmed, M.]]
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[[Category: Lenardo MJ]]
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[[Category: Lenardo, M J.]]
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[[Category: Wan F]]
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[[Category: Wan, F.]]
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[[Category: Wang L]]
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[[Category: Wang, L.]]
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[[Category: Wu H]]
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[[Category: Wu, H.]]
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[[Category: Yang JK]]
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[[Category: Yang, J K.]]
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[[Category: Zheng L]]
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[[Category: Zheng, L.]]
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[[Category: Death effector domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:05:32 2008''
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Current revision

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition

PDB ID 2bbz

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