2bgs

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[[Image:2bgs.gif|left|200px]]
 
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==HOLO ALDOSE REDUCTASE FROM BARLEY==
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The line below this paragraph, containing "STRUCTURE_2bgs", creates the "Structure Box" on the page.
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<StructureSection load='2bgs' size='340' side='right'caption='[[2bgs]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BGS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2bgs| PDB=2bgs | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bgs OCA], [https://pdbe.org/2bgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bgs RCSB], [https://www.ebi.ac.uk/pdbsum/2bgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bgs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HORVU ALDR_HORVU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/2bgs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bgs ConSurf].
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<div style="clear:both"></div>
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'''HOLO ALDOSE REDUCTASE FROM BARLEY'''
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==See Also==
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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In most higher plants a period of desiccation is the terminal event in embryogenesis. Excised barley embryos acquire desiccation tolerance at a precise developmental stage and cDNA clones have been isolated which are temporally linked with desiccation tolerance. One such clone (pG22-69) with a putative gene product of 34 kd displays high structural homology to mammalian genes encoding an NADPH dependent aldose reductase involved in the synthesis of sorbitol. This first aldose reductase gene of plants is expressed constitutively during embryo maturation and is modulated by the plant hormones abscisic acid (ABA) and gibberellic acid (GA). Immunohistochemistry showed that the protein is preferentially expressed in tissues formed at early stages in embryogenesis. Measurements of enzymatic activity indicate that pG22-69 encodes an active aldose reductase. The finding of this reductase activity and the cloning of the corresponding gene supports the existence of a metabolic pathway in plants playing a role in the synthesis of osmolytes like sorbitol. The significance of this work is that genes of related structure and functions are being used in diverse organisms to fulfil stress related biological requirements.
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==About this Structure==
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2BGS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BGS OCA].
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==Reference==
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An ABA and GA modulated gene expressed in the barley embryo encodes an aldose reductase related protein., Bartels D, Engelhardt K, Roncarati R, Schneider K, Rotter M, Salamini F, EMBO J. 1991 May;10(5):1037-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1827067 1827067]
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[[Category: Aldehyde reductase]]
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[[Category: Hordeum vulgare]]
[[Category: Hordeum vulgare]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Christensen, C L.]]
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[[Category: Christensen CL]]
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[[Category: Henriksen, A.]]
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[[Category: Henriksen A]]
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[[Category: Olsen, J G.]]
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[[Category: Olsen JG]]
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[[Category: Olsen, O.]]
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[[Category: Olsen O]]
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[[Category: Pedersen, L.]]
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[[Category: Pedersen L]]
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[[Category: Aldo/keto reductase]]
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[[Category: Aldose reductase]]
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[[Category: Holoenzyme]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:15:58 2008''
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Current revision

HOLO ALDOSE REDUCTASE FROM BARLEY

PDB ID 2bgs

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