2f15
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2f15" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f15, resolution 2.00Å" /> '''Glycogen-Binding Do...) |
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| - | [[Image:2f15.gif|left|200px]]<br /> | ||
| - | <applet load="2f15" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2f15, resolution 2.00Å" /> | ||
| - | '''Glycogen-Binding Domain Of The Amp-Activated Protein Kinase beta2 Subunit'''<br /> | ||
| - | == | + | ==Glycogen-Binding Domain Of The Amp-Activated Protein Kinase beta2 Subunit== |
| - | + | <StructureSection load='2f15' size='340' side='right'caption='[[2f15]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2f15]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F15 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f15 OCA], [https://pdbe.org/2f15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f15 RCSB], [https://www.ebi.ac.uk/pdbsum/2f15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f15 ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/AAKB2_HUMAN AAKB2_HUMAN] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). | |
| - | + | == Evolutionary Conservation == | |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f15_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | [[ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f15 ConSurf]. |
| - | [ | + | <div style="clear:both"></div> |
| - | [[ | + | |
| - | [ | + | |
| - | + | ||
| - | + | ==See Also== | |
| + | *[[AMP-activated protein kinase 3D structures|AMP-activated protein kinase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith C]] | ||
| + | [[Category: Bochkarev A]] | ||
| + | [[Category: Dhe-Paganon S]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Finerty Jr PJ]] | ||
| + | [[Category: MacKenzie FM]] | ||
| + | [[Category: Newman E]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Walker JR]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Wybenga-Groot L]] | ||
Current revision
Glycogen-Binding Domain Of The Amp-Activated Protein Kinase beta2 Subunit
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