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| - | [[Image:2f83.gif|left|200px]]<br /> | + | #REDIRECT [[6i58]] This PDB entry is obsolete and replaced by 6i58 |
| - | <applet load="2f83" size="450" color="white" frame="true" align="right" spinBox="true"
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| - | caption="2f83, resolution 2.87Å" />
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| - | '''Crystal structure of a human coagulation factor'''<br />
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| - | ==Overview==
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| - | Factor XI (FXI), a coagulation protein essential to normal hemostasis, circulates as a disulfide-linked dimer. Here we report the full-length FXI, zymogen crystal structure, revealing that the protease and four apple, domains assemble into a unique 'cup and saucer' architecture. The, structure shows that the thrombin and platelet glycoprotein Ib binding, sites are remote within the monomer but lie in close proximity across the, dimer, suggesting a transactivation mechanism.
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| - | ==Disease==
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| - | Known diseases associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]], Factor XI deficiency, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]]
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| - | ==About this Structure==
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| - | 2F83 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and PT as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2F83 OCA].
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| - | ==Reference==
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| - | Crystal structure of the factor XI zymogen reveals a pathway for transactivation., Papagrigoriou E, McEwan PA, Walsh PN, Emsley J, Nat Struct Mol Biol. 2006 Jun;13(6):557-8. Epub 2006 May 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16699514 16699514]
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| - | [[Category: Coagulation factor XIa]]
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Single protein]]
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| - | [[Category: Emsley, J.]]
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| - | [[Category: McEwan, P.A.]]
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| - | [[Category: Papagrigoriou, E.]]
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| - | [[Category: Walsh, P.N.]]
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| - | [[Category: NAG]]
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| - | [[Category: PT]]
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| - | [[Category: apple domain]]
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| - | [[Category: protease]]
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:00:59 2007''
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