This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2c46

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:05, 13 December 2023) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2c46.gif|left|200px]]
 
-
<!--
+
==CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase==
-
The line below this paragraph, containing "STRUCTURE_2c46", creates the "Structure Box" on the page.
+
<StructureSection load='2c46' size='340' side='right'caption='[[2c46]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2c46]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C46 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c46 OCA], [https://pdbe.org/2c46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c46 RCSB], [https://www.ebi.ac.uk/pdbsum/2c46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c46 ProSAT]</span></td></tr>
-
{{STRUCTURE_2c46| PDB=2c46 | SCENE= }}
+
</table>
-
 
+
== Function ==
-
'''CRYSTAL STRUCTURE OF THE HUMAN RNA GUANYLYLTRANSFERASE AND 5'-PHOSPHATASE'''
+
[https://www.uniprot.org/uniprot/MCE1_HUMAN MCE1_HUMAN] Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==About this Structure==
+
Check<jmol>
-
2C46 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C46 OCA].
+
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c46_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c46 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: MRNA guanylyltransferase]]
+
[[Category: Arrowsmith C]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Bunkoczi G]]
-
[[Category: Bunkoczi, G.]]
+
[[Category: Debreczeni J]]
-
[[Category: Debreczeni, J.]]
+
[[Category: Edwards A]]
-
[[Category: Delft, E Von.]]
+
[[Category: Gileadi O]]
-
[[Category: Edwards, A.]]
+
[[Category: Johansson C]]
-
[[Category: Gileadi, O.]]
+
[[Category: Knapp S]]
-
[[Category: Johansson, C.]]
+
[[Category: Longman E]]
-
[[Category: Knapp, S.]]
+
[[Category: SavitskySmee P]]
-
[[Category: Longman, E.]]
+
[[Category: Smee C]]
-
[[Category: Savitskysmee, P.]]
+
[[Category: Sundstrom M]]
-
[[Category: Smee, C.]]
+
[[Category: Ugochukwu E]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Weigelt J]]
-
[[Category: Ugochukwu, E.]]
+
[[Category: Von Delft F]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: Alternative splicing]]
+
-
[[Category: Guanylyltransferase]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Mrna capping]]
+
-
[[Category: Mrna processing]]
+
-
[[Category: Multifunctional enzyme]]
+
-
[[Category: Nuclear protein]]
+
-
[[Category: Nucleotidyltransferase]]
+
-
[[Category: Phosphatase]]
+
-
[[Category: Transferase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:13:22 2008''
+

Current revision

CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase

PDB ID 2c46

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c46"
Personal tools